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Central effects of camphor on GnRH and sexual hormones in male rat
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| Sima Shahabi1, Seyed Gholam Ali Jorsaraei2, Ali Akbar Moghadamnia3, Ebrahim Zabihi4, Seyed Mohsen Aghajanpour Mir4, Seyedeh Narges Mousavi Kani4, Roghiyeh Pourbagher4, Seyed Ahmad Hosseini5, Mohsen Esmaili5, Ali Asghar Yoonesi5, Amin Zarghami5, Farid Alinezhad5 |
1- Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. , sima.shahabi@ymail.com
2- Fatemeh Zahra Fertility and Infertility Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran.
3- Department of Physiology and Pharmacology, Babol University of Medical Sciences, Babol, Iran.
4- Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran.
5- Student Research Committee, Babol University of Medical Sciences, Babol, Iran. |
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Abstract: (16296 Views) |
| In Persian traditional medicine is believed that camphor (a crystalline ketone obtained from cinnamomum camphora) is a suppressor of sexual behaviors. This study examined the central effects of camphor on sexual hormones (LH, FSH and testosterone) and GnRH plasma levels in male rat.
Male Wistar rats weighing 250-260gr were selected and divided into control (no treatment), sham (ICV injection of EtOH 10%) and treatment (ICV injection of camphor in three doses 4, 20, 40 µg/ 10µl in alcohol) groups. The serum samples were used for assaying of GnRH, LH, FSH and testosterone.
There were no significant differences in the levels of hormones between the groups of study.
Despite the central administration of camphor in hypothalamus - pituitary - gonad (HPG) axis, no significant differences were seen in sex hormone`s levels compared to the control. With this finding, it can be concluded that camphor may not effectively handle the axis via central pathway. These data recommend further studies of camphor on the HPG axis. |
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| Keywords: Camphor, GnRH, LH, FSH, Testosterone, Hypothalamus - Pituitary - Gonad (H-P-G) Axis |
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Full-Text [PDF 57 kb]
(3838 Downloads)
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Type of Study: Original Article |
Subject:
Clinical Biochemistry
Received: 2013/02/18 | Accepted: 2013/05/11 | Published: 2013/05/11
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