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:: Volume 1, Issue 4 (Int J Mol Cell Med 2012) ::
Int J Mol Cell Med 2012, 1(4): 191-196 Back to browse issues page
Central effects of camphor on GnRH and sexual hormones in male rat
Sima Shahabi * 1, Seyed Gholam Ali Jorsaraei 2, Ali Akbar Moghadamnia 3, Ebrahim Zabihi 4, Seyed Mohsen Aghajanpour Mir 4, Seyedeh Narges Mousavi Kani 4, Roghiyeh Pourbagher 4, Seyed Ahmad Hosseini 5, Mohsen Esmaili 5, Ali Asghar Yoonesi 5, Amin Zarghami 5, Farid Alinezhad 5
1- Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. , sima.shahabi@ymail.com
2- Fatemeh Zahra Fertility and Infertility Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran.
3- Department of Physiology and Pharmacology, Babol University of Medical Sciences, Babol, Iran.
4- Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran.
5- Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Abstract:   (10660 Views)
In Persian traditional medicine is believed that camphor (a crystalline ketone obtained from cinnamomum camphora) is a suppressor of sexual behaviors. This study examined the central effects of camphor on sexual hormones (LH, FSH and testosterone) and GnRH plasma levels in male rat. Male Wistar rats weighing 250-260gr were selected and divided into control (no treatment), sham (ICV injection of EtOH 10%) and treatment (ICV injection of camphor in three doses 4, 20, 40 µg/ 10µl in alcohol) groups. The serum samples were used for assaying of GnRH, LH, FSH and testosterone. There were no significant differences in the levels of hormones between the groups of study. Despite the central administration of camphor in hypothalamus - pituitary - gonad (HPG) axis, no significant differences were seen in sex hormone`s levels compared to the control. With this finding, it can be concluded that camphor may not effectively handle the axis via central pathway. These data recommend further studies of camphor on the HPG axis.
Keywords: Camphor, GnRH, LH, FSH, Testosterone, Hypothalamus - Pituitary - Gonad (H-P-G) Axis
Full-Text [PDF 57 kb]   (2244 Downloads)    
Type of Study: Original Article | Subject: Clinical Biochemistry
Received: 2013/02/18 | Accepted: 2013/05/11 | Published: 2013/05/11
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shahabi S, Jorsaraei S G A, Moghadamnia A A, Zabihi E, Aghajanpour Mir S M, Mousavi Kani S N, et al . Central effects of camphor on GnRH and sexual hormones in male rat. Int J Mol Cell Med. 2012; 1 (4) :191-196
URL: http://ijmcmed.org/article-1-71-en.html


Volume 1, Issue 4 (Int J Mol Cell Med 2012) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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