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Evaluation of PKM2 and MAPK8IP2 polymorphism in Ameloblastic Carcinoma: A retrospective quantitative study
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Abbas Khodayari1   , Sayyed Mohammad Hossein Ghaderian 2, Mohammad Jafarian1 , Alireza Jahangirnia3 , Alireza Nayebi4 , Fahimeh Akhlaghi1 , Nasim Taghavi5 , Reza Akbarzadeh Najar6 , Sanaz Tabarestani7 , Arash Khojasteh1 , Sarah Aghabozorg Afjeh6 |
1- Department of Oral and Maxillofacial Surgery, Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , sghaderian@yahoo.co.uk
3- Department of Oral and Maxillofacial Surgery,Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4- Department of Oral and Maxillofacial Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5- Department of oral and maxillofacial pathology, dental faculty,Shahid beheshty university of medical science,Tehran, Iran.
6- Department of Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
7- Department of Genetics, Shahid Beheshti university of Medical Sciences, Tehran,Iran. |
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Abstract: (17099 Views) |
| Ameloblastic carcinoma (AC) is a rare malignant epithelial odontogenic tumor that histologically retains the features of ameloblastic differentiation and exhibits cytological features of malignancy in the primary or recurrent tumor. It may develop within a preexisting ameloblastoma or arise de novo or from an odontogenic cyst. Epidemiological evidence shows that human cancer is generally caused by genotoxic factors, genes involved in the susceptibility of cancer, including those involved in metabolism or detoxification of genotoxic environment and those controlling DNA replication. Nowadays, gene polymorphism has an important role in development of malignant tumor. We report a case series study of ameloblastic carcinoma and ameloblastoma to show the role of PKM2 and MAPK8IP2 polymorphisms in these tumors. The DNA was extracted separately from specimens in paraffin sections of the tumor. Polymorphism of these genes was determined by PCR-RFLP (Polymerase Chain Reaction-Restriction fragment length polymorphism) method. The allele distributions of all samples were in Hardy-Weinberg equilibrium. The genotype and allele distribution in these genes were not statistically different between patients and controls. |
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| Keywords: Ameloblastic carcinoma, PKM2, MAPK8IP2, polymorphism |
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Full-Text [PDF 293 kb]
(3333 Downloads)
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Type of Study: Original Article |
Subject:
Genetics & Disease
Received: 2013/02/8 | Accepted: 2013/03/17 | Published: 2013/03/17
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