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:: Volume 1, Issue 4 (Int J Mol Cell Med 2012) ::
Int J Mol Cell Med 2012, 1(4): 203-208 Back to browse issues page
Evaluation of PKM2 and MAPK8IP2 polymorphism in Ameloblastic Carcinoma: A retrospective quantitative study
Abbas Khodayari 1, Sayyed Mohammad Hossein Ghaderian * 2, Mohammad Jafarian 1, Alireza Jahangirnia 3, Alireza Nayebi 4, Fahimeh Akhlaghi 1, Nasim Taghavi 5, Reza Akbarzadeh Najar 6, Sanaz Tabarestani 7, Arash Khojasteh 1, Sarah Aghabozorg Afjeh 6
1- Department of Oral and Maxillofacial Surgery, Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , sghaderian@yahoo.co.uk
3- Department of Oral and Maxillofacial Surgery,Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4- Department of Oral and Maxillofacial Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5- Department of oral and maxillofacial pathology, dental faculty,Shahid beheshty university of medical science,Tehran, Iran.
6- Department of Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
7- Department of Genetics, Shahid Beheshti university of Medical Sciences, Tehran,Iran.
Abstract:   (10609 Views)
Ameloblastic carcinoma (AC) is a rare malignant epithelial odontogenic tumor that histologically retains the features of ameloblastic differentiation and exhibits cytological features of malignancy in the primary or recurrent tumor. It may develop within a preexisting ameloblastoma or arise de novo or from an odontogenic cyst. Epidemiological evidence shows that human cancer is generally caused by genotoxic factors, genes involved in the susceptibility of cancer, including those involved in metabolism or detoxification of genotoxic environment and those controlling DNA replication. Nowadays, gene polymorphism has an important role in development of malignant tumor. We report a case series study of ameloblastic carcinoma and ameloblastoma to show the role of PKM2 and MAPK8IP2 polymorphisms in these tumors. The DNA was extracted separately from specimens in paraffin sections of the tumor. Polymorphism of these genes was determined by PCR-RFLP (Polymerase Chain Reaction-Restriction fragment length polymorphism) method. The allele distributions of all samples were in Hardy-Weinberg equilibrium. The genotype and allele distribution in these genes were not statistically different between patients and controls.
Keywords: Ameloblastic carcinoma, PKM2, MAPK8IP2, polymorphism
Full-Text [PDF 293 kb]   (1650 Downloads)    
Type of Study: Original Article | Subject: Genetics & Disease
Received: 2013/02/8 | Accepted: 2013/03/17 | Published: 2013/03/17
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Khodayari A, Ghaderian S M H, Jafarian M, Jahangirnia A, Nayebi A, Akhlaghi F, et al . Evaluation of PKM2 and MAPK8IP2 polymorphism in Ameloblastic Carcinoma: A retrospective quantitative study. Int J Mol Cell Med. 2012; 1 (4) :203-208
URL: http://ijmcmed.org/article-1-65-en.html


Volume 1, Issue 4 (Int J Mol Cell Med 2012) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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