International Journal of Molecular and Cellular Medicine (IJMCM)
Cellular and Molecular Biology Research Center, Babol University of Medical Sciences
Thu, Nov 21, 2024
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Volume 12, Issue 4 (Int J Mol Cell Med 2023)
Int J Mol Cell Med 2023, 12(4): 335-349 |
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Rezvan H, Ali S A, Hamoon Navard S, Rees R. Biological Activity of Mouse OX40L-Igg Purified With Two Novel Resins. Int J Mol Cell Med 2023; 12 (4) :335-349
URL: http://ijmcmed.org/article-1-2171-en.html
URL: http://ijmcmed.org/article-1-2171-en.html
1- , h.rezvan@basu.ac.ir
2- School of Science, Nottingham Trent University, Clifton Lane, Clifton, Nottingham, NG11 8NS, UK.
3- Department of Pathobiology, Faculty of Veterinary Sciences, Bu-Ali Sina University, Hamedan, Iran.
4- Department of Life Sciences, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK.
2- School of Science, Nottingham Trent University, Clifton Lane, Clifton, Nottingham, NG11 8NS, UK.
3- Department of Pathobiology, Faculty of Veterinary Sciences, Bu-Ali Sina University, Hamedan, Iran.
4- Department of Life Sciences, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK.
Abstract: (533 Views)
One of the important stimulating molecules for the function of T lymphocytes is tumor necrosis factor receptor OX40 (CD134), activated by its cognate ligand OX40L (CD134L, CD252). OX40L interactions have been proposed as a potential therapeutic target for treating infectious and non-infectious diseases. The main purpose of this study was to determine the potency of two novel resins MBI and MEP for the purification of OX40L-IgG fusion protein and the biological activities of this OX40L-IgG fusion protein. The biological activity of the OX40L-IgG purified by these resins compared with protein A sepharose resin. Mice treated with the same doses of the OX40L purified by the three resins showed a significant delay in tumor growth compared to the controls injected with PBS. Mice treated with the OX40L purified by MBI resin showed a significant delay in tumor cell (CT26) growth compared with mice injected with OX40L purified by other resins.
Type of Study: Original Article |
Subject:
Molecular & Cellular Immunology
Received: 2023/06/10 | Accepted: 2024/04/7 | Published: 2024/05/25
Received: 2023/06/10 | Accepted: 2024/04/7 | Published: 2024/05/25
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