دوره 12، شماره 4 - ( 7-1402 )                   | برگشت به فهرست نسخه ها

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Rezvan H, Ali S A, Hamoon Navard S, Rees R. Biological Activity of Mouse OX40L-Igg Purified With Two Novel Resins. Int J Mol Cell Med 2023; 12 (4) :335-349
URL: http://ijmcmed.org/article-1-2171-fa.html
Biological Activity of Mouse OX40L-Igg Purified With Two Novel Resins. مجله بین المللی سلولی و مولکولی. 1402; 12 (4) :335-349

URL: http://ijmcmed.org/article-1-2171-fa.html

Biological Activity of Mouse OX40L-Igg Purified With Two Novel Resins
:   (534 مشاهده)
One of the important stimulating molecules for the function of T lymphocytes is tumor necrosis factor receptor OX40 (CD134), activated by its cognate ligand OX40L (CD134L, CD252). OX40L interactions have been proposed as a potential therapeutic target for treating infectious and non-infectious diseases. The main purpose of this study was to determine the potency of two novel resins MBI and MEP for the purification of OX40L-IgG fusion protein and the biological activities of this OX40L-IgG fusion protein. The biological activity of the OX40L-IgG purified by these resins compared with protein A sepharose resin. Mice treated with the same doses of the OX40L purified by the three resins showed a significant delay in tumor growth compared to the controls injected with PBS. Mice treated with the OX40L purified by MBI resin showed a significant delay in tumor cell (CT26) growth compared with mice injected with OX40L purified by other resins.
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نوع مطالعه: Original Article | موضوع مقاله: Molecular & Cellular Immunology
دریافت: 1402/3/20 | پذیرش: 1403/1/19 | انتشار: 1403/3/5
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