Volume 9, Issue 3 (Int J Mol Cell Med 2020)                   Int J Mol Cell Med 2020, 9(3): 198-206 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Pourteymour Fard Tabrizi Z, Miraj S, Tahmasebian S, Ghasemi S. Plasma Levels of miR-27a, miR-130b, and miR-301a in Polycystic Ovary Syndrome. Int J Mol Cell Med 2020; 9 (3) :198-206
URL: http://ijmcmed.org/article-1-1272-en.html
Plasma Levels of miR-27a, miR-130b, and miR-301a in Polycystic Ovary Syndrome
Zahra Pourteymour Fard Tabrizi1 , Sepideh Miraj2 , Shahram Tahmasebian3 , Sorayya Ghasemi4
1- Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
2- Department of Obstetrics and Gynecology, Shahrekord University of Medical Sciences, Shahrekord, Iran.
3- School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.
4- Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran. , sorayya.ghasemi@gmail.com
Abstract:   (4838 Views)
Polycystic ovary syndrome (PCOS) is a gynecological endocrine disorder in women of reproductive age. There is adequate evidence that suggests several microRNAs (miRNAs) are of great importance for PCOS. It seems that dysregulated expression of miR-27a, miR-130b, and miR-301a are associated with PCOS. The aim of this study was to investigate whether plasma levels of these miRNAs are different between patients with PCOS and healthy controls. 53 women with a definite diagnosis of PCOS, and 53 healthy controls were enrolled. MiRNAs expression levels in plasma were evaluated by real-time PCR. The diagnostic values of each miRNA were calculated by the receiver operating characteristic (ROC) curve and areas under the curves (AUC). The main clinical characteristics were not significantly different between the two groups. The circulating plasma expression levels of miR-27a and miR-301a had a significant increase (P = 0.0008 and P < 0.0001, respectively) but miR-130b expression level decreased in the patient group (P < 0.0001). The AUC for miR-27a, miR-130b, and miR-301a were 0.71, 0.77, and 0.66, respectively. A positive exponential was observed for miR-27a and miR-301a in multiple logistic regression. Changes in the plasma expressions of the studied miRNAs are likely to be associated with PCOS phenotypes. MiR-27a has a potential to serve as a diagnostic biomarker of PCOS.
Keywords: Polycystic ovary syndrome, plasma, miRNA-27a, miRNA-130b, miRNA-301a
Full-Text [PDF 397 kb]   (1841 Downloads)    
Type of Study: Original Article | Subject: Biomarkers (diagnosis & treatment)
Received: 2020/03/8 | Accepted: 2020/09/6 | Published: 2020/08/20
Add your comments about this article : Your username or Email:
CAPTCHA
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 CC BY-NC 4.0 | International Journal of Molecular and Cellular Medicine IJMCM

Designed & Developed by : Yektaweb