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:: Volume 9, Issue 3 (Int J Mol Cell Med (In Press) 2020) ::
Int J Mol Cell Med 2020, 9(3): 0-0 Back to browse issues page
Plasma Levels of miR-27a, miR-130b, and miR-301a in Polycystic Ovary Syndrome
Zahra Pourteymour Fard Tabrizi1, Sepideh Miraj2, Shahram Tahmasebian3, Sorayya Ghasemi 4
1- Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
2- Department of Obstetrics and Gynecology, Shahrekord University of Medical Sciences, Shahrekord, Iran.
3- School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.
4- Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran. , sorayya.ghasemi@gmail.com
Abstract:   (111 Views)
Polycystic ovary syndrome (PCOS) is a gynecological endocrine disorder in women of reproductive age. There is adequate evidence that suggests several microRNAs (miRNAs) are of great importance for PCOS. It seems that dysregulated expression of miR-27a, miR-130b, and miR-301a are associated with PCOS. The aim of this study was to investigate whether plasma levels of these miRNAs are different between patients with PCOS and healthy controls. 53 women with a definite diagnosis of PCOS, and 53 healthy controls were enrolled. MiRNAs expression levels in plasma were evaluated by real-time PCR. The diagnostic values of each miRNA were calculated by the receiver operating characteristic (ROC) curve and areas under the curves (AUC). The main clinical characteristics were not significantly different between the two groups. The circulating plasma expression levels of miR-27a and miR-301a had a significant increase (P = 0.0008 and P < 0.0001, respectively) but miR-130b expression level decreased in the patient group (P < 0.0001). The AUC for miR-27a, miR-130b, and miR-301a were 0.71, 0.77, and 0.66, respectively. A positive exponential was observed for miR-27a and miR-301a in multiple logistic regression. Changes in the plasma expressions of the studied miRNAs are likely to be associated with PCOS phenotypes. MiR-27a has a potential to serve as a diagnostic biomarker of PCOS.
Keywords: Polycystic ovary syndrome, plasma, miRNA-27a, miRNA-130b, miRNA-301a
Full-Text [PDF 395 kb]   (26 Downloads)    
Type of Study: Original Article | Subject: Biomarkers (diagnosis & treatment)
Received: 2020/03/8 | Accepted: 2020/09/6 | Published: 2020/08/20
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Pourteymour Fard Tabrizi Z, Miraj S, Tahmasebian S, Ghasemi S. Plasma Levels of miR-27a, miR-130b, and miR-301a in Polycystic Ovary Syndrome. Int J Mol Cell Med. 2020; 9 (3)
URL: http://ijmcmed.org/article-1-1272-en.html


Volume 9, Issue 3 (Int J Mol Cell Med (In Press) 2020) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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