[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
Submission ::
Ethics::
Registration::
Contact us::
Site Facilities::
::
Impact Factor
Impact Factor 2022: 1.9
5-Year Impact Factor: 2.2
Cite Score 2022: 3.9
SJR 2022: 0.447
SNIP 2022: 0.538

 
..
Publication Fee
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 11, Issue 3 (Int J Mol Cell Med 2022) ::
Int J Mol Cell Med 2022, 11(3): 197-206 Back to browse issues page
Vitexin Induces Apoptosis in MCF-7 Breast Cancer Cells through the Regulation of Specific miRNAs Expression
Reza Najafipour1 , Abdolmabood Momeni2 , Yoosef Mirmazloomi3 , Sahar Moghbelinejad 4
1- Genetics Research Center, the University of Social Welfare and Rehabilitation Science, Tehran, Iran.
2- Khatam pathobiology and genetics lab, Qazvin, Iran.
3- School of Medicine, Qazvin University of Medical Sciences, Shahid Bahonar Boulevard, Qazvin, Iran.
4- Research Institute for Prevention of Non-Communicable Diseases, Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, Shahid Bahonar Boulevard, Qazvin, Iran. , smoghbelinejad@qums.ac.ir
Abstract:   (620 Views)

In this research, we investigated microRNAs (miRNAs) expression profile in MCF-7 breast cancer cell line which treated with 150 µM vitexine. Profiling of miRNAs expression was performed using TaqMan MiRNA Array. Apoptosis was analyzed by flow cytometry and the expression of some genes involved in "anti-proliferative" signaling pathways were evaluated by western blotting and real time PCR methods. Twenty microRNAs were differentially expressed in vitexine treated cells compared to the control. Among them, let-7-b,c  were up regulated while miRNA-17-5p was down regulated with highest score. Also, we detected the expression changes of mentioned miRNAs target genes as well as genes involved in caspase apoptosis pathways. Our results provide the first evidence that vitexin can effect miRNA expression in MCF-7 cells. Also based on our finding, vitexin can be an attractive miRNA mediated chemo preventive and therapeutic agent in breast cancer.

Keywords: Vitexin, MicroRNA, breast cancer, apoptosis
Full-Text [PDF 551 kb]   (179 Downloads)    
Type of Study: Original Article | Subject: Cancer
Received: 2022/09/7 | Accepted: 2023/07/9 | Published: 2023/07/9
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Najafipour R, Momeni A, Mirmazloomi Y, Moghbelinejad S. Vitexin Induces Apoptosis in MCF-7 Breast Cancer Cells through the Regulation of Specific miRNAs Expression. Int J Mol Cell Med 2022; 11 (3) :197-206
URL: http://ijmcmed.org/article-1-2006-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 11, Issue 3 (Int J Mol Cell Med 2022) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
Persian site map - English site map - Created in 0.07 seconds with 38 queries by YEKTAWEB 4624