Evaluation of Placentalmir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia

Azizi, Faezeh; Saleh Gargari, Soraya; Asadi Shahmirzadi, Sedigheh; Dodange, Fatemeh; Amiri, Vahid; Mirfakhraie, Reza; Omrani, Mir Davood

doi:10.22088/acadpub.BUMS.6.1.22

International Journal of Molecular and Cellular Medicine (IJMCM)

Cellular and Molecular Biology Research Center, Babol University of Medical Sciences

Sun, Jun 1, 2025 [Archive]

Volume 6, Issue 1 (Int J Mol Cell Med 2017) Int J Mol Cell Med 2017, 6(1): 22-30 | Back to browse issues page

‎ 10.22088/acadpub.BUMS.6.1.22

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Azizi F, Saleh Gargari S, Asadi Shahmirzadi S, Dodange F, Amiri V, Mirfakhraie R et al . Evaluation of Placentalmir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia. Int J Mol Cell Med 2017; 6 (1) :22-30
URL: http://ijmcmed.org/article-1-628-en.html

Evaluation of Placentalmir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia

Faezeh Azizi¹

, Soraya Saleh Gargari²

, Sedigheh Asadi Shahmirzadi³

, Fatemeh Dodange³

, Vahid Amiri⁴

, Reza Mirfakhraie¹

, Mir Davood Omrani⁵

1- Department of Medical Genetics, Faculty of Medicine, ShahidBeheshtiUniversity of Medical Sciences,Tehran, Iran.
2- Feto-Maternal Unit, ShohadayeTajrish Hospital, ShahidBeheshti, University of Medical Sciences, Tehran, Iran.
3- Feto-Maternal Unit, Mahdiyeh Hospital, ShahidBeheshti, University of Medical Sciences, Tehran, Iran.
4- School of Allied Medical Sciences,ShahidBeheshti, University of Medical Sciences, Tehran, Iran.
5- Department of Medical Genetics, Faculty of Medicine, ShahidBeheshtiUniversity of Medical Sciences,Tehran, Iran. , Davood_omrani@yahoo.co.uk

Abstract: (8655 Views)

It has been well documented that preeclampsia (PE) has a common etiological background, but little is known about its linkage at the molecular level.Non- coding RNAs are critical posttranscriptional regulators ofgene expression. This study was performed to determine whether PEis associated with alterations in placental non-codingRNAs expression. MicroRNA(miR)-155-5p and long non-coding RNA (lnc)sONE expression, in placentas collected sequentially from 59 patients with PE and 40 normotensive pregnancies were measured using real-time PCR.The relationship between miR-155-5p and lncsONE expressions wasanalyzed statistically. miR-155-5p expression was increased(fold change=1.6, P=0.04), whilelncsONE expression was not significantly changed(fold change=1.1, P=0.68), in placentas from patients compared with control group.miR-155-5p was upregulated in placentas from patients with PEand may have influencedeNOS expression. These findings indicate that miRNA-155-5p may be involved in PE pathogenesis and could be a potential biomarker for this disease.