Enhancing Osteogenesis in Dental Implants: The Role of ZNF710-AS1 and miR-146a-5p in Smad Signaling Pathway Activation

Mahmoudi Anzabi, Reza; Shenasa, Naghmeh; Jafarian, Ali; Davodpour, Amir Hossein; Zareanshahraki, Mehran; Ghasemirad, Mohammad; Rostamzadeh, Sajjad

Volume 0 - Int J Mol Cell Med (Inprees) Int J Mol Cell Med 2025, 0 - Int J Mol Cell Med (Inprees): 0-0 | Back to browse issues page

Mendeley

Zotero

RefWorks

Mahmoudi Anzabi R, Shenasa N, Jafarian A, Davodpour A H, Zareanshahraki M, Ghasemirad M et al . Enhancing Osteogenesis in Dental Implants: The Role of ZNF710-AS1 and miR-146a-5p in Smad Signaling Pathway Activation. Int J Mol Cell Med 2025;
URL: http://ijmcmed.org/article-1-2522-en.html

Enhancing Osteogenesis in Dental Implants: The Role of ZNF710-AS1 and miR-146a-5p in Smad Signaling Pathway Activation

Reza Mahmoudi Anzabi¹

, Naghmeh Shenasa²

, Ali Jafarian³

, Amir Hossein Davodpour⁴

, Mehran Zareanshahraki⁵

, Mohammad Ghasemirad⁶

, Sajjad Rostamzadeh⁷

1- Resident of Orthodontics at the Department of Orthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
2- Endodontics Department, Shahrekord University of Medical Science, Private Practice, Shahrekord, Iran.
3- Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
4- Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
5- UCLA School of Dentistry preceptorship surgical implant dentistry, Los Angeles, California, United States of America
6- Department of Periodontics, Faculty of Dentistry, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
7- Department of Orthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran , sajjadrostamzadeh1@gmail.com

Abstract: (77 Views)

Investigations have shown that understanding the regulatory mechanisms of the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) can significantly enhance the regenerative capacity of periodontal tissues and mitigate periodontal disorders. Improving osteogenesis in dental implants is complex, requiring better bone regeneration and integration with the implant surface. ZNF710-AS1 is identified as a key regulator of osteogenic differentiation via the BMP6/Smad pathway, with the overexpression of miR-146a-5p and miR-146b-5p inhibiting ZNF710-AS1's osteogenic effects. This study explores the role of the long noncoding RNA ZNF710-AS1 in PDLSC osteogenic differentiation and clarifies its molecular mechanisms. Results indicate that ZNF710-AS1 expression positively influences osteogenic differentiation, while miR-146a-5p has a suppressive effect. ZNF710-AS1 serves as a competing endogenous RNA (ceRNA) for miR-146a-5p, increasing BMP6 levels and activating the Smad signaling pathway. The study also highlights the role of miR-146a-5p, in osteogenesis and inflammation in peri-implant tissues. Findings suggest miR-146a-5p promotes osteogenic differentiation and could be a potential biomarker for periodontal conditions. In summary, this research provides key insights into the molecular mechanisms of osteogenesis and advocates for targeting ZNF710-AS1 and miR-146a-5p to improve dental implant integration and regenerative strategies for periodontal tissues.

Keywords: Osteogenic differentiation, ZNF710-AS1, miR-146a-5p, Regulation

Full-Text [PDF 712 kb] (23 Downloads)

Type of Study: Review | Subject: Cell Biology
Received: 2024/12/31 | Accepted: 2025/03/7 | Published: 2025/07/19