Volume 13, Issue 4 (Int J Mol Cell Med 2024)                   Int J Mol Cell Med 2024, 13(4): 417-435 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Vakilzadehian N, Moradi Y, B. Allela O Q, Fawzi Al-Hussainy A, Ali Al-Nuaimi A M, A_al-hussein R K, et al . Non-coding RNA in the Regulation of Gastric Cancer Tumorigenesis: Focus on microRNAs and Exosomal microRNAs. Int J Mol Cell Med 2024; 13 (4) :417-435
URL: http://ijmcmed.org/article-1-2424-en.html
Non-coding RNA in the Regulation of Gastric Cancer Tumorigenesis: Focus on microRNAs and Exosomal microRNAs
Niyousha Vakilzadehian1 , Yasamin Moradi2 , Omer Qutaiba B. Allela3 , Ali Fawzi Al-Hussainy4 , Ali M. Ali Al-Nuaimi5 , Rouaida Kadhim A_al-hussein6 , Mahmood Jasem Jawad7 , Hossein Gandomkar8 , Samaneh Moradi9
1- Department of Pharmacology and Pharmacotherapy, faculty of medicine, University of Debrecen, 4032 Debrecen, Hungary.
2- School of Pharmacy and Bioengineering, Keele University, Guy Hilton Research Centre, Stoke-on-Trent, United Kingdom.
3- College of Pharmacy, Alnoor University, Nineveh, Iraq.
4- College of Pharmacy, Ahl Al Bayt University, Kerbala, Iraq.
5- Gilgamesh Ahliya University, Baghdad, Iraq.
6- Collage of Nursing, National University of Science and Technology, Dhi Qar, 64001, Iraq.
7- Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq.
8- Department of Surgical Oncology, Tehran University of Medical Medicine, Tehran, Iran.
9- Departments of Internal Medical, Shiraz University of Medical Sciences, Shiraz ,Iran. , Samanehmoradi6756@gmail.com
Abstract:   (700 Views)
Gastric cancer has become the leading type of cancer on an international scale, with metastatic cancer being the leading cause of mortality associated with this illness. Consequently, methods for early detection have been established, mainly through the use of non-invasive biomarkers present in different bodily fluids. Exosomes are distinct extracellular vehicles that transport cellular signals over long distances via diverse contents. They may be readily seen in bodily fluids due to their secretion by gastric cancer cells or cells in the gastric cancer-tumor microenvironment. Given this context, multiple biological and functional features of human tumors, especially gastric cancer, are intricately connected to exosomal non-coding RNAs (ncRNAs). Exosomal microRNAs play a crucial role in several stages of gastric cancer progression, facilitating the transfer of genetic information between cancer cells and other cells. This process regulates tumor angiogenesis, growth, metastasis, immunological responses, and medication resistance. They engage with several regulatory complexes that have different enzymatic activities. These complexes then alter the chromatin landscapes, including changes to nucleosomes, DNA methylation, and alterations to histones. This research delves into the essential regulatory mechanisms of exosomes in gastric cancer. Furthermore, the existing understanding of the functions of exosomal miRNAs in this context was evaluated, aiming to confirm their potential significance in identifying biomarkers, elucidating their roles in immune evasion and drug resistance, and ultimately evaluating therapeutic strategies.
Keywords: Non-coding RNA, ncRNA, gastric cancer, tumorigenesis, exosomal microRNAs
Full-Text [PDF 458 kb]   (278 Downloads)    
Type of Study: Review | Subject: Cancer
Received: 2024/08/28 | Accepted: 2024/10/9 | Published: 2024/12/14
Add your comments about this article : Your username or Email:
CAPTCHA
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 CC BY-NC 4.0 | International Journal of Molecular and Cellular Medicine IJMCM

Designed & Developed by : Yektaweb