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Effect of Capparis spinosa Fruit Hydroalcoholic Extract on Paraquat-Induced Pulmonary Fibrosis in the Rat
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Tahmine Ostovar1   , Sahar Rezaei Arablouydareh2 , Hajar Shokri-Afra3 , Sadra Samavarchi Tehrani4 , Fatemeh Namvarjah5 , Masoume Aliabadi6 , Hosein Effatpanah 7, Hemen Moradi-Sardareh8 |
1- International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2- Department of Clinical Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
3- Gut and Liver Research Center, Non-communicable Disease Institute, Mazandaran University of Medical Sciences, Sari, Iran.
4- Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Science, Tehran, Iran.
5- Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
6- Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
7- Department of Public Health, Asadabad School of Medical Sciences, Asadabad, Iran. , m.effatpanah@gmail.com
8- Asadabad School of Medical Science, Asadabad, Iran. |
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Abstract: (347 Views) |
| Pulmonary fibrosis (PF) is a lethal inflammatory disease and there has been no effective medication for this progressive disease up to now. Paraquat is commonly used in agricultural settings to control weed growth and is one of the important risk factors for PF. Additionally, emerging evidence has demonstrated Capparis spinosa (C. spinose) fruit extract has anti-fibrotic, anti-inflammatory, and antioxidant properties. We aimed to evaluate whether C. spinose fruit hydroalcoholic extract has a positive effect against Paraquat-induced PF in rats. 30 male Wistar rats were randomly divided into 5 groups, which included: a control group, a Paraquat control group, a C. spinose group with a dose of 20 mg/kg, a C. spinose group with a dose of 30 mg/kg, a C. spinose group with a dose of 50 mg/kg. After 21 days of the treatment, levels of hydroxyproline and malondialdehyde (MDA) in lung tissue were assessed and lung indices and semi-quantitative histopathological changes were determined. The results showed that treatment with C. spinose, led to increased weight gain, whereas reduced lung weight. C. spinose demonstrated a decreasing effect on levels of MDA, and hydroxyproline in lung tissue. Moreover, histopathological data and the number of lung indices indicated the preventive role of C. spinose Paraquat-induced PF in rats. |
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| Keywords: Pulmonary fibrosis, Paraquat, malondialdehyde, Hydroxyproline |
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Full-Text [PDF 913 kb]
(113 Downloads)
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Type of Study: Original Article |
Subject:
Clinical Biochemistry
Received: 2023/10/25 | Accepted: 2024/04/8 | Published: 2024/05/25
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