|
Lactoferrin and Activated Protein C: Potential Role in Prevention of Cancer Progression and Recurrence
|
Nahid Akhtar1   , Atif Khurshid Wani1 , Musamey Jan1 , Shruti Sinha2 , Hari Prasad Devkota3 , Zijian Li4 , Amin-ul Mannan1 , Ajit Prakash  5 |
1- School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab-144411, India.
2- Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, United States of America.
3- Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
4- Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, United States of America.
5- Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, United States of America. , ajit@ad.unc.edu |
|
|
Abstract: (1303 Views) |
| Existing therapeutic interventions for controlling cancer are limited and associated with side effects. Furthermore, the recurrence of cancer poses a significant challenge to the cure of cancer. Therefore, avenues are wanted to find novel therapies for cancer treatment and cancer recurrence. In this review, we have highlighted that lactoferrin (LF) and activated protein C (APC) carry enormous potential in cancer treatment. Studies have shown that the decreased level of APC and impaired function of APC are associated with cancer progression and cancer-related mortality. Moreover, APC plays an important role in preventing prothrombotic state-mediated cancer progression and deaths. LF can also inhibit the progression of cancer by controlling the generation of reactive oxygen species, triggering the apoptosis of cancer cells, arresting the cell cycle and hindering the angiogenesis process. Additionally, APC and LF could have the potential to inhibit neutrophil extracellular traps (NETs) formations which are involved in cancer progression and the reawakening of dormant cancer cells. Hence, in this review, the anticancer potential and mechanism of APC and LF along with their potential to mitigate inflammation and NETs-mediated cancer progression and recurrence has been discussed. Additionally, possible future strategies to develop effective and safe anticancer treatment using LF and APC have also been discussed in this review. |
|
| Keywords: Cancer, activated protein C, Lactoferrin, neutrophil extracellular traps, cancer treatment |
|
|
Full-Text [PDF 637 kb]
(389 Downloads)
|
Type of Study: Review |
Subject:
Cancer
Received: 2023/08/18 | Accepted: 2023/10/14 | Published: 2023/09/19
|
|
|
|
|
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
