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Prevalence of Co-infection by Human Papillomavirus, Epstein-Barr Virus and Merkel Cell Polyomavirus in Iranian Oral Cavity Cancer and Pre-malignant Lesions
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Sagahr Saber Amoli1    , Ali Hasanzadeh2 , Farzin Sadeghi3 , Mohammad Chehrazi4 , Maryam Seyedmajidi5 , Arghavan Zebardast6 , Yousef Yahyapour 7 |
1- Department of Medical Microbiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
2- Department of Medical Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
3- Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
4- Department of Biostatistics and Epidemiology, School of Public Health, Babol University of Medical Sciences, Babol, Iran.
5- Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
6- Department Medical Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
7- Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. , uyahyapoor@yahoo.com |
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Abstract: (2126 Views) |
Human papillomavirus (HPV) is recognized as a most important risk factor in oral cavity cancer and pre-malignant lesions; however, etiological association of concomitant infection with other oncogenic viruses as a co-factor has not been definitively proven. The present study aimed to determine the prevalence of co-infection with HPV, Epstein–Barr virus (EBV) and Merkel Cell PolyomaVirus (MCPyV) in oral cavity lesions in Iranian patients. One hundred and fourteen oral cavity samples, including 33 oral squamous cell carcinoma, 28 oral lichen planus, 16 oral epithelial dysplasia and 37 oral irritation fibromas were analyzed for the HPV, EBV and MCPyV infection by quantitative real-time PCR. According to histological features 32.5% and 28.9% of cases were oral irritation fibroma and oral squamous cell carcinoma, respectively. Infection with at least two viruses was detected in 21.1% of patients. In this group, co-infection with HPV/EBV was identified in 37.5% of cases, HPV/MCPyV in 29.2%, EBV/MCPyV in 12.5%, and HPV/EBV/MCPyV in 20.8%. There was no statistically significant difference between multiple infections and anatomical locations of cancer. The prevalence of triple viral infection (HPV/EBV/MCPyV) in well differentiated tumors was higher than EBV or MCPyV single infection. This study revealed that co-infection of HPV, EBV and MCPyV can be detected in both malignant and non-malignant oral cavity tissues, and co-infection with all three viruses in well differentiated tumors can be shown as a synergistic hypothesis of the pathogenic role of these viruses in oral malignant transformation.
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| Keywords: Co-infection, human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), Epstein–Barr virus (EBV), oral lesions |
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Full-Text [PDF 441 kb]
(621 Downloads)
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Type of Study: Original Article |
Subject:
Infectious disease (Molecular and Cellular aspects)
Received: 2022/02/20 | Accepted: 2022/06/11 | Published: 2022/06/20
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Saber Amoli S, Hasanzadeh A, Sadeghi F, Chehrazi M, Seyedmajidi M, Zebardast A et al . Prevalence of Co-infection by Human Papillomavirus, Epstein-Barr Virus and Merkel Cell Polyomavirus in Iranian Oral Cavity Cancer and Pre-malignant Lesions. Int J Mol Cell Med 2022; 11 (1) :64-77 URL: http://ijmcmed.org/article-1-1873-en.html
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