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Evaluation of pre-treatment serum levels of IL-7 and GM-CSF in colorectal cancer patients
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Mehdi Taghipour Fard Ardekani1   , Mahyar Malekzadeh1 , Mohammad Vahid Hosseini2 , Elahe Bordbar1 , Zahra Mojtahei1 , Mehrnoosh Doroudchi 3, Abbas Ghaderi1 |
1- Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
2- Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
3- Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. , mdoroud@sums.ac.ir |
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Abstract: (11545 Views) |
| Background: Survival of Colorectal cancer (CRC) patients is considerably stage-dependent therefore, early diagnosis is a pivotal factor in decreasing mortality and morbidity associated with this cancer. GM-CSF and IL-7 are reported to increase in different cancers and we aim to investigate the pre-treatment serum levels of GM-CSF and IL-7 in Iranian patients with colorectal cancer.
Methods: 127 patients (68 males and 59 females) before receiving chemotherapy or radiotherapy entered to this study. A control group of 50 healthy age/sex matched individuals (27 males and 23 females) were included in the study. Serum levels of GM-CSF and IL-7 were measured using commercial enzyme linked immunosorbent assays.
Results: A significantly higher level of GM-CSF was found in the sera of patients with colorectal cancer compared with healthy age/sex matched controls (p=0.013). However, there was no significant difference between the levels of IL-7 in sera of patients and controls. We observed a significant elevation in the level of GM-CSF in poorly differentiated tumors (p=0.024). Also a significant correlation between lymphatic invasion and the level of GM-CSF in sera of CRC patients was detected (p=0.01). We found an increase in the level of IL-7 in the three patients in the moderate stages of the tumor concomitant with a decrease in the level of GM-CSF.
Conclusion: Increase in the level of GM-CSF is accompanied by CRC progression in Iranian patients, while there may be a potential therapeutic effect of IL-7 in this disease. |
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| Keywords: Colorectal cancer, Serum, GM-CSF, IL-7 |
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Full-Text [PDF 141 kb]
(3562 Downloads)
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Type of Study: Original Article |
Subject:
Cancer
Received: 2013/10/17 | Accepted: 2013/12/15 | Published: 2013/12/25
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