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:: Volume 8 - Suppl 1_Int J Mol Cell Med ::
Int J Mol Cell Med 2019, 8 - Suppl 1_Int J Mol Cell Med: 49-55 Back to browse issues page
The Role of ERRFI1+808T/G Polymorphism in Diabetic Nephropathy
Saeedeh Asgarbeik1 , Mahsa Mohammad Amoli2 , Samaneh Enayati3 , Fatemeh Bandarian4 , Ensieh Nasli-Esfahani5 , Katayoon Forouzanfar6 , Farideh Razi 7, Seyed Abdolhamid Angaji1
1- Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
2- Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
3- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
4- Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
5- Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
6- Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
7- Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. , swt_f@yahoo.com
Abstract:   (5771 Views)
Nephropathy is a common diabetes complication. ERRFI1 gene which participates in various cellular pathways has been proposed as a candidate gene in diabetic nephropathy. This study aimed to investigate the role of +808T/G polymorphism (rs377349) in ERRFI1 gene in diabetic nephropathy. In this case-control study, patients including diabetes with nephropathy (DN=104), type 2 diabetes without nephropathy (DM=100), and healthy controls (HC=106) were included. DNA was extracted from blood, and genotyping of the +808T/G polymorphism was carried out using PCR-RFLP technique. The differences for genotype and allele frequencies for +808T/G polymorphism in ERRFI1 gene between DN vs. HC and DN+DM vs. HC were significant (P<0.05) while no significant difference between DN and DM was observed. The allele frequencies were significantly different in DN vs. HC and DN+DM vs. HC in males but not in females. G allele of +808T/G polymorphism in ERRFI1 gene has no significant role in development and progression of diabetic nephropathy in diabetes patients while it is a risk allele for developing diabetes in Iranian population.
Keywords: ERRFI1, +808T/G, polymorphism, rs397349, diabetic nephropathy
Full-Text [PDF 311 kb]   (1755 Downloads)    
Type of Study: Original Article | Subject: Genetics & Disease
Received: 2019/03/13 | Accepted: 2019/06/6 | Published: 2019/07/5
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Asgarbeik S, Mohammad Amoli M, Enayati S, Bandarian F, Nasli-Esfahani E, Forouzanfar K, et al . The Role of ERRFI1+808T/G Polymorphism in Diabetic Nephropathy. Int J Mol Cell Med 2019; 8 (S1) :49-55
URL: http://ijmcmed.org/article-1-1043-en.html


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Volume 8 - Suppl 1_Int J Mol Cell Med Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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