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:: Volume 12, Issue 3 (Int J Mol Cell Med 2023) ::
Int J Mol Cell Med 2023, 12(3): 300-309 Back to browse issues page
Sex-based Dysregulation of Inflammation-related Genes in Periodontitis
Soudeh Ghafouri-Fard1 , Leila Gholami2 , Elham Badrlou1 , Saba Sadeghpour1 , Naghme Nazer3 , Mahdi Shadnoush4 , Sheyda Khalilian1 , Arezou Sayad 5
1- Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Department of Periodontics, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
3- Department of Electrical Engineering, Sharif University of Technology, Tehran, Iran.
4- Department of Clinical Nutrition, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5- Dental Research Center, Research Institute for Dental Sciences, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , ar.sayad@yahoo.com
Abstract:   (772 Views)

Periodontitis is a chronic inflammatory condition affecting a large population all over the world. This condition is linked with abnormal expression of numerous genes. We measured levels of CYFIP1, KDR, RABGGTA, RABGGTB and FOXD2 in gingival tissue and circulation of people with periodontitis and healthy controls. KDR was more expressed in tissue samples of female patients compared with female controls (Ratio of mean expression (RME) =4.16, P=0.02). However, this gene was less expressed in the blood of female patients compared with female control subjects (RME=0.12, P=0.04). RABGGTB was less expressed in the blood of male patients compared with male controls (RME=0.20, P=0.02). Finally, FOXD2 was less expressed in total blood samples compared with total controls (RME=0.3, P<0.001) and in blood samples of female patients compared with female control subjects (RME=0.02, P<0.001). RABGGTA had the best area under curve (AUC) value in differentiation of patients' tissues from normal tissues (AUC=0.60, sensitivity=0.37, specificity=0.92). In distinction of abnormal blood samples from controls, FOXD2 had the best performance (AUC=0.85, sensitivity=0.66, specificity=0.91). In brief, we demonstrated a sex-dependent dysregulation of KDR, RABGGTB and FOXD2 genes in circulation or tissue of patients with periodontitis.

Keywords: CYFIP1, KDR, RABGGTA, RABGGTB, FOXD2, periodontitis
Full-Text [PDF 663 kb]   (283 Downloads)    
Type of Study: Original Article | Subject: Genetics & Disease
Received: 2023/10/23 | Accepted: 2024/01/14 | Published: 2024/02/18
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Ghafouri-Fard S, Gholami L, Badrlou E, Sadeghpour S, Nazer N, Shadnoush M, et al . Sex-based Dysregulation of Inflammation-related Genes in Periodontitis. Int J Mol Cell Med 2023; 12 (3) :300-309
URL: http://ijmcmed.org/article-1-2232-en.html


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Volume 12, Issue 3 (Int J Mol Cell Med 2023) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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