HER-2/neu Marker Examination using Immunohistochemical Method in Patients Suffering from Gastric Adenocarcinoma

Movagharnejad, Kourosh; Sharbatdaran, Majid; Shefaee, Shahryar; Kashifard, Mehrdad; Sedaghat, Sadegh

Volume 2, Issue 4 (Int J Mol Cell Med 2013) Int J Mol Cell Med 2013, 2(4): 199-203 | Back to browse issues page

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Movagharnejad K, Sharbatdaran M, Shefaee S, Kashifard M, Sedaghat S. HER-2/neu Marker Examination using Immunohistochemical Method in Patients Suffering from Gastric Adenocarcinoma. Int J Mol Cell Med 2013; 2 (4) :199-203
URL: http://ijmcmed.org/article-1-94-en.html

HER-2/neu Marker Examination using Immunohistochemical Method in Patients Suffering from Gastric Adenocarcinoma

Kourosh Movagharnejad¹

, Majid Sharbatdaran²

, Shahryar Shefaee³

, Mehrdad Kashifard⁴

, Sadegh Sedaghat⁵

1- Department of pathology, Rohani hospital, Babol University of Medical Sciences, Babol, Iran.
2- Department of pathology, Rohani hospital, Babol University of Medical Sciences, Babol, Iran. , sharbatdaran@yahoo.com
3- Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran.
4- Department of Internal medicine , Rohani hospital, Babol University of Medical Sciences, Babol, Iran.
5- Department of Hematology and Oncology, Rohani hospital, Babol University of Medical Sciences, Babol, Iran.

Abstract: (15844 Views)

Gastric adenocarcinoma is the second leading cause of death due to cancer in the world and in advanced stages the prognosis is poor with current therapies. Over-expression of HER-2/neu has been seen in several cancers such as gastric cancer and its expression is associated with poor prognosis. The aim of this study is to evaluate the over-expression of HER-2/neu in gastric biopsy samples of patients with gastric carcinoma diagnosis and to evaluate its probable relationship with clinical and pathological findings. The over-expression of HER-2/neu was examined retrospectively by immunohistochemistry method in 60 paraffin embedded samples collected in Babol, Iran, between 2010 and 2011. The over-expression of HER-2/neu has been observed in 6 patients (10%) and this over-expression was greater in the intestinal type of gastric adenocarcinoma than the diffuse type (12% vs. 6%) however, no statistically significant correlation between HER-2/neu expression and subtype, degree of differentiation, tumor type and age was observed. This over-expression was greater in differentiated types than undifferentiated types (18% vs. 5%).

Keywords: HER-2/neu, gastric cancer, immunohistochemistry

Full-Text [PDF 147 kb] (3391 Downloads)

Type of Study: Original Article | Subject: Histopathology
Received: 2013/07/10 | Accepted: 2013/11/24 | Published: 2013/11/24