International Journal of Molecular and Cellular Medicine (IJMCM)
Cellular and Molecular Biology Research Center, Babol University of Medical Sciences
Sat, Dec 21, 2024
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Volume 13, Issue 2 (Int J Mol Cell Med 2024)
Int J Mol Cell Med 2024, 13(2): 198-209 |
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Eghbalpour K, Eghbalpour N, Khademi S, Arzi L. Suppressive Potential of Rosmarinus officinalis L. Extract against Triple-Negative and Luminal A Breast Cancer. Int J Mol Cell Med 2024; 13 (2) :198-209
URL: http://ijmcmed.org/article-1-2372-en.html
URL: http://ijmcmed.org/article-1-2372-en.html
1- Department of Biology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran.
2- Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran. ,Laleh.arzi@ut.ac.ir
2- Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran. ,
Abstract: (522 Views)
Rosemary is an aromatic plant with ancient and modern applications as a spice and herbal remedy. Due to the strong antioxidant potential of rosemary, the present study investigated the anti-proliferative and pro-apoptotic characteristics of rosemary on luminal A and triple-negative breast cancer cells. The effect of rosemary extract on the WNT10B and β-Catenin genes was also evaluated. The WNT10B and β-Catenin expression were measured by real-time PCR. The outcomes of the MTT assay and AnnexinV/PI flow cytometry assay showed that exposure of MCF-7 and MDA-MB-231 cells to rosemary reduced cell viability in a dose-time-dependent routine and promoted apoptosis in breast cancer cells. It was revealed that the extract could exert cytotoxic and apoptotic effects by downregulation of WNT10B and β-Catenin. Our results suggest rosemary as a promising complementary herbal medicine for breast cancers, without the adverse effects of chemotherapy drugs.
Keywords: Rosmarinus officinalis, luminal A, triple-negative breast cancer, anti-proliferative, pro-apoptotic, Wnt/ β-catenin
Type of Study: Original Article |
Subject:
Infectious disease (Molecular and Cellular aspects)
Received: 2024/06/22 | Accepted: 2024/07/17 | Published: 2024/08/10
Received: 2024/06/22 | Accepted: 2024/07/17 | Published: 2024/08/10
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