دوره 13، شماره 2 - ( 2-1403 )                   | برگشت به فهرست نسخه ها

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Eghbalpour K, Eghbalpour N, Khademi S, Arzi L. Suppressive Potential of Rosmarinus officinalis L. Extract against Triple-Negative and Luminal A Breast Cancer. Int J Mol Cell Med 2024; 13 (2) :198-209
URL: http://ijmcmed.org/article-1-2372-fa.html
Suppressive Potential of Rosmarinus officinalis L. Extract against Triple-Negative and Luminal A Breast Cancer. مجله بین المللی سلولی و مولکولی. 1403; 13 (2) :198-209

URL: http://ijmcmed.org/article-1-2372-fa.html

Suppressive Potential of Rosmarinus officinalis L. Extract against Triple-Negative and Luminal A Breast Cancer
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Rosemary is an aromatic plant with ancient and modern applications as a spice and herbal remedy. Due to the strong antioxidant potential of rosemary, the present study investigated the anti-proliferative and pro-apoptotic characteristics of rosemary on luminal A and triple-negative breast cancer cells. The effect of rosemary extract on the WNT10B and β-Catenin genes was also evaluated. The WNT10B and β-Catenin expression were measured by real-time PCR.  The outcomes of the MTT assay and AnnexinV/PI flow cytometry assay showed that exposure of MCF-7 and MDA-MB-231 cells to rosemary reduced cell viability in a dose-time-dependent routine and promoted apoptosis in breast cancer cells. It was revealed that the extract could exert cytotoxic and apoptotic effects by downregulation of WNT10B and β-Catenin. Our results suggest rosemary as a promising complementary herbal medicine for breast cancers, without the adverse effects of chemotherapy drugs.
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نوع مطالعه: Original Article | موضوع مقاله: Infectious disease (Molecular and Cellular aspects)
دریافت: 1403/4/2 | پذیرش: 1403/4/27 | انتشار: 1403/5/20
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