Megavoltage X-ray Dose Enhancement with Gold Nanoparticles in Tumor Bearing Mice

Mousavie Anijdan, Sayyed Hossein; Mahdavi, Seied Rabi; Shirazi, Alireza; Zarrinfard, Mohammad Ali; Hajati, Jamshid

Volume 2, Issue 3 (Int J Mol Cell Med 2013) Int J Mol Cell Med 2013, 2(3): 118-124 | Back to browse issues page

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Mousavie Anijdan S H, Mahdavi S R, Shirazi A, Zarrinfard M A, Hajati J. Megavoltage X-ray Dose Enhancement with Gold Nanoparticles in Tumor Bearing Mice. Int J Mol Cell Med 2013; 2 (3) :118-124
URL: http://ijmcmed.org/article-1-95-en.html

Megavoltage X-ray Dose Enhancement with Gold Nanoparticles in Tumor Bearing Mice

Sayyed Hossein Mousavie Anijdan¹

, Seied Rabi Mahdavi²

, Alireza Shirazi²

, Mohammad Ali Zarrinfard³

, Jamshid Hajati⁴

1- Department of Medical Physics, Babol University of Medical Sciences, Babol, Iran. , hmousavi@razi.tums.ac.ir
2- Department of Medical Physics and Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
3- Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
4- Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Abstract: (12052 Views)

One of the applications of gold nanoparticles (GNPs) in medicine is radiation dose-enhancing effect. Although there are many simulations, in vitro and in vivo evidence that GNPs can enhance significantly the radiation dose effect of orthovoltage beams. These beams compared with megavoltage (MV) beams, have limited applications in radiotherapy. In order to evaluate GNPs radiosensitization performance with MV beams in-vivo, we used two most clinically used X-ray beams (6 and 18 MV) with the dose of 20 Gy for each mouse. Intratumoral injection of 50 nm GNPs with the concentration of 5 mg ml-1 was applied to melanoma tumor growing in the left leg of 7 to 8 mice in 4 control and treatment groups of C57BL/6 mice. Albeit, using 10 cm plexiglass jig phantom in the beam path improved the radiation - treatments, the statistical differences between groups were not significant. According to the results, it is concluded that mice can be treated with smaller tumors and higher concentrations of GNPs in MV radiation beams.

Keywords: Gold nanoparticles (GNPs), radiation dose enhancement, tumor, megavoltage X-ray

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Type of Study: Original Article | Subject: Nanomedicine
Received: 2013/07/13 | Accepted: 2013/08/28 | Published: 2013/08/28