[صفحه اصلی ]   [Archive]  
:: صفحه اصلي :: درباره نشريه :: آخرين شماره :: تمام شماره‌ها :: جستجو :: ثبت نام :: ارسال مقاله :: تماس با ما ::
:: دوره 2، شماره 3 - ( 5-1392 ) ::
برگشت به فهرست نسخه ها
Megavoltage X-ray Dose Enhancement with Gold Nanoparticles in Tumor Bearing Mice
:   (7801 مشاهده)
One of the applications of gold nanoparticles (GNPs) in medicine is radiation dose-enhancing effect. Although there are many simulations, in vitro and in vivo evidence that GNPs can enhance significantly the radiation dose effect of orthovoltage beams. These beams compared with megavoltage (MV) beams, have limited applications in radiotherapy. In order to evaluate GNPs radiosensitization performance with MV beams in-vivo, we used two most clinically used X-ray beams (6 and 18 MV) with the dose of 20 Gy for each mouse. Intratumoral injection of 50 nm GNPs with the concentration of 5 mg ml-1 was applied to melanoma tumor growing in the left leg of 7 to 8 mice in 4 control and treatment groups of C57BL/6 mice. Albeit, using 10 cm plexiglass jig phantom in the beam path improved the radiation - treatments, the statistical differences between groups were not significant. According to the results, it is concluded that mice can be treated with smaller tumors and higher concentrations of GNPs in MV radiation beams.
متن کامل [PDF 183 kb]   (1824 دریافت)    
نوع مطالعه: Original Article | موضوع مقاله: Nanomedicine
دریافت: ۱۳۹۲/۴/۲۲ | پذیرش: ۱۳۹۲/۶/۶ | انتشار: ۱۳۹۲/۶/۶
ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

CAPTCHA


XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mousavie Anijdan S H, Mahdavi S R, Shirazi A, Zarrinfard M A, Hajati J. Megavoltage X-ray Dose Enhancement with Gold Nanoparticles in Tumor Bearing Mice. Int J Mol Cell Med. 2013; 2 (3) :118-124
URL: http://ijmcmed.org/article-1-95-fa.html

Megavoltage X-ray Dose Enhancement with Gold Nanoparticles in Tumor Bearing Mice. مجله بین المللی سلولی و مولکولی. 1392; 2 (3) :118-124

URL: http://ijmcmed.org/article-1-95-fa.html



دوره 2، شماره 3 - ( 5-1392 ) برگشت به فهرست نسخه ها
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
Persian site map - English site map - Created in 0.06 seconds with 32 queries by YEKTAWEB 4030