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Cellular response to ionizing radiation: A microRNA story
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| Mohammad Halimi1, Mohsen Asghari1, Reyhaneh Sariri1, Dariush Moslemi2, Hadi Parsian 3 |
1- Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.
2- Department of Radiation oncology, Babol University of Medical Sciences, Babol, Iran.
3- Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran. |
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Abstract: (11715 Views) |
| MicroRNAs (miRNAs) represent a class of small non-coding RNA molecules that regulate gene expression at the post-transcriptional level. They play a crucial role in diverse cellular pathways. Ionizing radiation (IR) is one of the most important treatment protocols for patients that suffer from cancer and affects directly or indirectly cellular integration. Recently it has been discovered that microRNA-mediated gene regulation interferes with radio-related pathways in ionizing radiation. Here, we review the recent discoveries about miRNAs in cellular response to IR. Thoroughly understanding the mechanism of miRNAs in radiation response, it will be possible to design new strategies for improving radiotherapy efficiency and ultimately cancer treatment. |
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| Keywords: Cellular response, ionizing radiation, microRNA |
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Full-Text [PDF 446 kb]
(3109 Downloads)
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Type of Study: Review |
Subject:
Biomarkers (diagnosis & treatment)
Received: 2013/02/11 | Accepted: 2013/07/3 | Published: 2013/07/3
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