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:: Volume 5, Issue 2 (Int J Mol Cell Med 2016) ::
Int J Mol Cell Med 2016, 5(2): 100-105 Back to browse issues page
The Relation between GABA and L-Arginine Levels with some Stroke Risk Factors in Acute Ischemic Stroke Patients
Mohsen Hosinian1, Durdi Qujeq2, Alijan Ahmadi Ahangar 3
1- Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
2- Cellular and Molecular Biology Research Center (CMBRC), Health Reasearch Institute, Babol University of Medical Sciences, Babol, Iran.
3- Mobility Impairment Research Center, Babol University of Medical Sciences, Babol, Iran. , ahmadiahangaralijan@yahoo.com
Abstract:   (5234 Views)

Changes in extra and intracellular neurotransmitter amino acids concentration in the early stage of acute cerebral ischemia have been reported. In this the study, serum level of gamma aminobutyric acid (GABA) and L-Arginine in acute ischemic stroke patients was assessed. 60 patients with acute ischemic stroke and sixthy healthy volunteers as a control group were assessed. Serum GABA was measured with modified enzymatic method and serum L- Arginine was measured by modified Sakaguchi method. Serum GABA level in stroke cases was lower than that of the control group. There was no relationship between GABA level and age or gender. Also, no significant correlation was observed between GABA levels with ischemic stroke risk factors such as smoking, diabetes mellitus, and hypertension. Serum L- Arginine level in patients was slightly increased in comparison with control group. There was a positive relationship between serum L- Arginine level and acute ischemic stroke risk factors. Serum GABA level was reduced in patients and had no correlation with acute ischemic stroke risk factors.

Keywords: Gamma aminobutyric acid (GABA), arginine, acute ischemic stroke
Full-Text [PDF 84 kb]   (1616 Downloads)    
Type of Study: Original Article | Subject: Neurosciences
Received: 2016/01/11 | Accepted: 2016/06/18 | Published: 2016/06/19
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Hosinian M, Qujeq D, Ahmadi Ahangar A. The Relation between GABA and L-Arginine Levels with some Stroke Risk Factors in Acute Ischemic Stroke Patients. Int J Mol Cell Med. 2016; 5 (2) :100-105
URL: http://ijmcmed.org/article-1-452-en.html


Volume 5, Issue 2 (Int J Mol Cell Med 2016) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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