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:: Volume 5, Issue 1 (Int J Mol Cell Med 2016) ::
Int J Mol Cell Med 2016, 5(1): 49-56 Back to browse issues page
Orosomucoid-1 Expression in Ameloblastoma Variants
Alejandro García-Muñoz1, Ronell Bologna-Molina2, Mario A. Rodríguez3, Rodrigo Liceaga-Reyes4, Jose Eduardo Farfán-Morales5, Saray Aranda-Romo6, Nelly Molina-Frechero7, Rogelio González-González 8
1- Laboratorio de Investigación en Odontología, ALMARAZ/UBIMED, FES Iztacala, UNAM. State of Mexico, Mexico.
2- Molecular Pathology, Universidad de la República (UDELAR), Montevideo, Uruguay.
3- Department of Infectomics and Molecular Pathogenesis, CINVESTAV-IPN, México, D.F, México.
4- Maxillofacial Surgery Department. Hospital Juárez de México, México D.F, México.
5- Instituto Nacional de Pediatría, México D.F, México.
6- Biochemistry, Microbiology and Pathology Laboratory, Faculty of Stomatology, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
7- Health Care Department, Universidad Autónoma Metropolitana, Xochimilco, UAM, México City, Mexico.
8- Department Research, School of Dentistry, Universidad Juárez del Estado de Durango, México. , rogegg@hotmail.com
Abstract:   (6990 Views)

Odontogenic tumors constitute a group of heterogeneous lesions of benign and malignant neoplasms with variable aggressiveness. Ameloblastomas are a group of benign but locally invasive neoplasms that occur in the jaws and are derived from epithelial elements of the tooth-forming apparatus. We previously described orosomucoid-1 protein expression in odontogenic myxomas. However, whether orosomucoid-1 is expressed in other odontogenic tumors remains unknown. Since orosomucoid-1 belongs to a group of acute-phase proteins and has many functions in health and disease, we identified and analyzed orosomucoid-1 expression in ameloblastoma variants and ameloblastic carcinoma using western blot and immunohistochemical techniques. Thirty cases of ameloblastoma were analyzed for orsomucoid-1; five specimens were fresh for western blot study (four benign ameloblastomas and one ameloblastic carcinoma), and 25 cases of benign ameloblastoma for immunohistochemical assays. Orosomucoid-1 was widely expressed in each tumor variant analyzed in this study, and differential orosomucoid-1 expression was observed between benign and malignant tumor. Orosomucoid-1 may play an important role in the behavior of ameloblastomas and influence the biology and development of the variants of this tumor.

Keywords: Orosomucoid-1, ameloblastoma, ameloblastic carcinoma, odontogenic tumors
Full-Text [PDF 505 kb]   (2315 Downloads)    
Type of Study: Original Article | Subject: Histopathology
Received: 2015/11/24 | Accepted: 2016/01/9 | Published: 2016/02/3
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García-Muñoz A, Bologna-Molina R, Rodríguez M A, Liceaga-Reyes R, Farfán-Morales J E, Aranda-Romo S, et al . Orosomucoid-1 Expression in Ameloblastoma Variants. Int J Mol Cell Med. 2016; 5 (1) :49-56
URL: http://ijmcmed.org/article-1-420-en.html

Volume 5, Issue 1 (Int J Mol Cell Med 2016) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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