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Orosomucoid-1 Expression in Ameloblastoma Variants
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Odontogenic tumors constitute a group of heterogeneous lesions of benign and malignant neoplasms with variable aggressiveness. Ameloblastomas are a group of benign but locally invasive neoplasms that occur in the jaws and are derived from epithelial elements of the tooth-forming apparatus. We previously described orosomucoid-1 protein expression in odontogenic myxomas. However, whether orosomucoid-1 is expressed in other odontogenic tumors remains unknown. Since orosomucoid-1 belongs to a group of acute-phase proteins and has many functions in health and disease, we identified and analyzed orosomucoid-1 expression in ameloblastoma variants and ameloblastic carcinoma using western blot and immunohistochemical techniques. Thirty cases of ameloblastoma were analyzed for orsomucoid-1; five specimens were fresh for western blot study (four benign ameloblastomas and one ameloblastic carcinoma), and 25 cases of benign ameloblastoma for immunohistochemical assays. Orosomucoid-1 was widely expressed in each tumor variant analyzed in this study, and differential orosomucoid-1 expression was observed between benign and malignant tumor. Orosomucoid-1 may play an important role in the behavior of ameloblastomas and influence the biology and development of the variants of this tumor.

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نوع مطالعه: Original Article | موضوع مقاله: Histopathology
دریافت: ۱۳۹۴/۹/۳ | پذیرش: ۱۳۹۴/۱۰/۱۹ | انتشار: ۱۳۹۴/۱۱/۱۴
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García-Muñoz A, Bologna-Molina R, Rodríguez M A, Liceaga-Reyes R, Farfán-Morales J E, Aranda-Romo S, et al . Orosomucoid-1 Expression in Ameloblastoma Variants. Int J Mol Cell Med. 2016; 5 (1) :49-56
URL: http://ijmcmed.org/article-1-420-fa.html

Orosomucoid-1 Expression in Ameloblastoma Variants. مجله بین المللی سلولی و مولکولی. 1394; 5 (1) :49-56

URL: http://ijmcmed.org/article-1-420-fa.html



دوره 5، شماره 1 - ( 11-1394 ) برگشت به فهرست نسخه ها
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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