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:: Volume 4, Issue 4 (Int J Mol Cell Med 2015) ::
Int J Mol Cell Med 2015, 4(4): 197-208 Back to browse issues page
Adipose- Derived Stem Cells as a Tool for Dental Implant Osseointegration: an Experimental Study in the Dog
Eriberto Bressan1, Daniele Botticelli2, Stefano Sivolella1, Franco Bengazi2, Riccardo Guazzo1, Luca Sbricoli1, Sara Ricci1, Letizia Ferroni3, Chiara Gardin3, Joaquin Urbizo Velez2, Barbara Zavan 3
1- Department of Neurosciences, University of Padua, Padua, Italy.
2- Faculty of Dentistry, University of Medical Science, La Habana, Cuba.
3- Department of Biomedical Sciences, University of Padua, Via Bassi 58, 35100 Padua, Italy.
Abstract:   (5563 Views)

The biological interaction between the jaw bones and dental implant is fundamental for the long-term success of dental implant placement. Nevertheless, the insufficient bone volume remains a major clinical problem, especially in case of immediate dental implant. Using a canine model, the present study proves the regenerative potential of adipose- derived stem cells (ADSCs) to repair peri-implant bone defects occurring in immediate dental implant placement. In six labradors, all mandibular premolars and the first molars were extracted bilaterally and three months later dental implants were installed with a marginal gap. The marginal defects were filled with hydroxyapatite (HA)-based scaffolds previously seeded with ADSCs. After one month of healing, specimens were prepared for histological and histomorphometric evaluations. Histological analyses of ground sections show that ADSCs significantly increase bone regeneration. Several new vessels, osteoblasts and new bone matrix were detected. By contrast, no inflammatory cells have been revealed. ADSCs could be used to accelerate bone healing in peri- implant defects in case of immediate dental implant placement.

Keywords: Adipose- derived stem cells, alveolar bone loss, peri- implant bone defect, immediate dental implant, bone regeneration, hydroxyapatite
Full-Text [PDF 413 kb]   (1698 Downloads)    
Type of Study: Original Article | Subject: Stem Cell
Received: 2015/07/30 | Accepted: 2015/09/2 | Published: 2015/09/20
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Bressan E, Botticelli D, Sivolella S, Bengazi F, Guazzo R, Sbricoli L, et al . Adipose- Derived Stem Cells as a Tool for Dental Implant Osseointegration: an Experimental Study in the Dog. Int J Mol Cell Med. 2015; 4 (4) :197-208
URL: http://ijmcmed.org/article-1-358-en.html


Volume 4, Issue 4 (Int J Mol Cell Med 2015) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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