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Abdollahi M, Zangooei M, Ghorbani P, Mahmoudian R A, Mansouri A. Achillea biebersteinii-Mediated Gold Nanoparticles on Oocyte Gene Expression and Follicular Development in Mice. Int J Mol Cell Med 2025;
URL: http://ijmcmed.org/article-1-2577-en.html
Achillea biebersteinii-Mediated Gold Nanoparticles on Oocyte Gene Expression and Follicular Development in Mice
Mohammadreza Abdollahi1 , Mohammad Zangooei2 , Parishad Ghorbani3 , Reihaneh Alsadat Mahmoudian4 , Atena Mansouri5
1- Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
2- Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
3- Department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
4- Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran. & Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
5- Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran , mansouri_atena@yahoo.com
Abstract:   (12 Views)

Background: This research aimed to compare the effects of chemical gold nanoparticles (GNPs) and green gold nanoparticles (gGNPs) derived from Achillea bielineeinii (AB) extract (gGNP) on antrum diameter.

Methods: The expression of genes linked to follicular development in NMRI mice. Real-time PCR and ImageJ software were utilized to evaluate gene expression and antrum diameter, respectively.

Results: The gGNPs notably increased the antrum diameter of secondary follicles at a dose of 100 μg/ml compared to that of the GNPs at the same dosage (p ≤ 0.05). The antrum diameter of the transplant follicles did not significantly differ across the experimental groups or from the control group. The real-time PCR results showed an increase in the expression of all studied genes (BMP-15, GDF-9, SOD, and GPx) in response to both GNP and gGNPs. However, the impact of gGNPs on gene expression was significantly more than that of GNPs (p ≤ 0.05), except for for the SOD gene.

Conclusions: Overall, these findings suggest that the use of AB enhances the effects of GNP on parameters associated with follicular development.

 

 

Keywords: Gold Nanoparticles, Achillea biebersteinii, Expression, Gene, Antrum
Full-Text [PDF 1052 kb]   (8 Downloads)    
Type of Study: Original Article | Subject: Cell Biology
Received: 2025/04/12 | Accepted: 2025/10/1 | Published: 2025/07/28
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