International Journal of Molecular and Cellular Medicine (IJMCM)
Cellular and Molecular Biology Research Center, Babol University of Medical Sciences
Tue, Feb 11, 2025
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Volume 10, Issue 1 (Int J Mol Cell Med 2021)
Int J Mol Cell Med 2021, 10(1): 1-10 |
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Noureddini M, Bagheri-Mohammadi S. Adult Hippocampal Neurogenesis and Alzheimer's Disease: Novel Application of Mesenchymal Stem Cells and their Role in Hippocampal Neurogenesis. Int J Mol Cell Med 2021; 10 (1) :1-10
URL: http://ijmcmed.org/article-1-1505-en.html
URL: http://ijmcmed.org/article-1-1505-en.html
1- Department of Physiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
2- Department of Physiology and Neurophysiology Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran ,bagherimohammadi-sa@sbmu.ac.ir
2- Department of Physiology and Neurophysiology Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran ,
Abstract: (5408 Views)
The neurogenesis can occur in two regions of the adult mammalian brain throughout the lifespan: the subgranular zone of the hippocampal dentate gyrus, and the subventricular zone of the lateral ventricle. The proliferation and maturation of neural progenitor cells are tightly regulated through intrinsic and extrinsic factors. The integration of maturated cells into the circuitry of the adult hippocampus emphasizes the importance of adult hippocampal neurogenesis in learning and memory. There is a large body of evidence demonstrating that alteration in the neurogenesis process in the adult hippocampus results in an early event in the course of Alzheimer disease (AD). In AD condition, the number and maturation of neurons declines progressively in the hippocampus. Innovative therapies are required to modulate brain homeostasis. Mesenchymal stem cells (MSCs) hold an immense potential to regulate the neurogenesis process, and are currently tested in some brain-related disorders, such as AD. Therefore, the aim of this review is to discuss the use of MSCs to regulate endogenous adult neurogenesis and their significant impact on future strategies for the treatment of AD.
Type of Study: Review |
Subject:
Neurosciences
Received: 2020/11/15 | Accepted: 2021/02/7 | Published: 2021/01/21
Received: 2020/11/15 | Accepted: 2021/02/7 | Published: 2021/01/21
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