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:: Volume 9, Issue 1 (Int J Mol Cell Med 2020) ::
Int J Mol Cell Med 2020, 9(1): 83-89 Back to browse issues page
Circulating CYTOR as a Potential Biomarker in Breast Cancer
Mohammad-Taher Moradi1, Reza Hatami2, Zohreh Rahimi 3
1- Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
2- Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
3- Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. , rahimizus@yahoo.com
Abstract:   (502 Views)
Long non-coding RNAs (lncRNAs) are newly introduced as tumor-related molecules. They are being considered as potential diagnostic and therapeutic targets in cancer studies. Here, we have assessed the importance of CYTOR (linc00152) as a biomarker for the detection of breast cancer in both tumoral tissue and plasma. The relative expression of breast cancer-associated CYTOR was measured in 20 tumoral and paired margin tissues, and moreover, in 80 plasma samples by real-time-polymerase chain reaction. In addition, plasma levels of CA 15-3 were measured using the ELISA test. The receiver operating characteristic curve (ROC) was applied for assessing the sensitivity and specificity of tested biomarkers. The results of the present study disclosed significantly increases in the CYTOR expression levels in tumor tissue with relative quantitation (RQ) equals to 5.15 (P<0.001) and in plasma (RQ =3.03, P<0.01) of breast cancer patients. The area under the ROC curve (AUC) of circulating CYTOR was 0.907 (95% CI: 0.842-0.972, P<0.001), while it was 0.868 (95% CI: 0.783–0.952, P<0.001) for CA 15-3. Based on these findings, we suggest lncRNA CYTOR as a new potential biomarker for breast cancer detection in both solid tumor tissue and plasma.
Keywords: Breast cancer, lncRNA, CYTOR, biomarker
Full-Text [PDF 480 kb]   (89 Downloads)    
Type of Study: Original Article | Subject: Biomarkers (diagnosis & treatment)
Received: 2020/01/9 | Accepted: 2020/06/13 | Published: 2020/04/29
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Moradi M, Hatami R, Rahimi Z. Circulating CYTOR as a Potential Biomarker in Breast Cancer. Int J Mol Cell Med. 2020; 9 (1) :83-89
URL: http://ijmcmed.org/article-1-1232-en.html


Volume 9, Issue 1 (Int J Mol Cell Med 2020) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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