[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 2, Issue 4 (Int J Mol Cell Med 2013) ::
Int J Mol Cell Med 2013, 2(4): 177-184 Back to browse issues page
Functional motifs in Escherichia coli NC101
Gholamreza Motalleb
Department of Biology, University of Zabol, Zabol, Iran. , rezamotalleb@gmail.com
Abstract:   (8656 Views)
Escherichia coli (E. coli) bacteria can damage DNA of the gut lining cells and may encourage the development of colon cancer according to recent reports. Genetic switches are specific sequence motifs and many of them are drug targets. It is interesting to know motifs and their location in sequences. At the present study, Gibbs sampler algorithm was used in order to predict and find functional motifs in E. coli NC101 contig 1. The whole genomic sequence of Escherichia coli NC101 contig 1 were retrieved from http://www.ncbi.nlm.nih.gov (NCBI Reference sequence: NZ_AEFA01000001.1) in order to be analyzed with DAMBE software and BLAST. The results showed that the 6-mer motif is CUGGAA in most sequences (genes1-3, 8, 9, 12, 14-18, 20-23, 25, 27, 29, 31-34), CUUGUA for gene 4 , CUGUAA for gene 5, CUGAUG for gene 6, CUGAUA for gene7, CUGAAA for genes 10, 11, 13, 26, 28, and CUGGAG for gene 19, and CUGGUA for gene30 in E. coli NC101 contig 1. It is concluded that the 6-mer motif is CUGGAA in most sequences in E. coli NC101 contig1. The present study may help experimental studies on elucidating the pharmacological and phylogenic functions of the motifs in E. coli.
Keywords: Escherichia coli, functional motifs, gene expression
Full-Text [PDF 93 kb]   (2315 Downloads)    
Type of Study: Original Article | Subject: Bioinformatic
Received: 2013/08/14 | Accepted: 2013/11/24 | Published: 2013/11/24
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Motalleb G. Functional motifs in Escherichia coli NC101 . Int J Mol Cell Med. 2013; 2 (4) :177-184
URL: http://ijmcmed.org/article-1-101-en.html


Volume 2, Issue 4 (Int J Mol Cell Med 2013) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 4162