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:: دوره 2، شماره 4 - ( 6-1392 ) ::
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Functional motifs in Escherichia coli NC101
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Escherichia coli (E. coli) bacteria can damage DNA of the gut lining cells and may encourage the development of colon cancer according to recent reports. Genetic switches are specific sequence motifs and many of them are drug targets. It is interesting to know motifs and their location in sequences. At the present study, Gibbs sampler algorithm was used in order to predict and find functional motifs in E. coli NC101 contig 1. The whole genomic sequence of Escherichia coli NC101 contig 1 were retrieved from http://www.ncbi.nlm.nih.gov (NCBI Reference sequence: NZ_AEFA01000001.1) in order to be analyzed with DAMBE software and BLAST. The results showed that the 6-mer motif is CUGGAA in most sequences (genes1-3, 8, 9, 12, 14-18, 20-23, 25, 27, 29, 31-34), CUUGUA for gene 4 , CUGUAA for gene 5, CUGAUG for gene 6, CUGAUA for gene7, CUGAAA for genes 10, 11, 13, 26, 28, and CUGGAG for gene 19, and CUGGUA for gene30 in E. coli NC101 contig 1. It is concluded that the 6-mer motif is CUGGAA in most sequences in E. coli NC101 contig1. The present study may help experimental studies on elucidating the pharmacological and phylogenic functions of the motifs in E. coli.
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نوع مطالعه: Original Article | موضوع مقاله: Bioinformatic
دریافت: ۱۳۹۲/۵/۲۳ | پذیرش: ۱۳۹۲/۹/۳ | انتشار: ۱۳۹۲/۹/۳
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Motalleb G. Functional motifs in Escherichia coli NC101 . Int J Mol Cell Med. 2013; 2 (4) :177-184
URL: http://ijmcmed.org/article-1-101-fa.html

Functional motifs in Escherichia coli NC101 . مجله بین المللی سلولی و مولکولی. 1392; 2 (4) :177-184

URL: http://ijmcmed.org/article-1-101-fa.html



دوره 2، شماره 4 - ( 6-1392 ) برگشت به فهرست نسخه ها
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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