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:: Volume 8, Issue 2 (Int J Mol Cell Med [In press] 2019) ::
Int J Mol Cell Med 2019, 8(2): 0-0 Back to browse issues page
Protective Effect of Naringin on Bisphenol A-Induced Cognitive Dysfunction and Oxidative Damage in Rats
Masoud Mahcavinia1, Akram Ahangharpoor2 , Lila Zeidooni3, Azin Samimi3, Mohammad Dehghani3, Saeid Alizadeh3, Soheila Alboghobeish 4
1- Department of Pharmacology and Toxicology, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, Iran.
2- Health Research Institute, Diabetes Research Center, Department of Physiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3- Department of Toxicology, School of Pharmacy, Student Research Committee of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
4- Department of Pharmacology, School of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran. , alboghobeish.s@ajums.ac.iir
Abstract:   (151 Views)
Bisphenol A (BPA) is one of the highest volume chemicals produced worldwide, which is used in many plastic industries. The present study aimed to evaluate the effect of BPA on cognitive functions and oxidative stress, and determine whether the naringin (NG) co-administration can modify the effect of this compound on cognitive functions and inhibit any possible oxidative stress in the brain tissue of rats. Adult male Wistar rats were divided into six groups. Group I: control, Group II: BPA-treated rats (50 mg/kg/day), Group III, IV, V: BPA+NG (40, 80, 160 mg/kg/day), Group VI: NG (160 mg/kg/day) alone. Cognitive functions were evaluated using step-down latency (SDL) on a passive avoidance apparatus, and transfer latency (TL) in elevated plus-maze. A significant decrease in SDL, prolongation of TL, noticeable oxidative impairment and increase in acetylcholinesterase activity were observed in the BPA-treated in comparison with the control group. Also, the co-administration of NG (160 mg/kg) antagonized the effect of BPA on SDL and TL, attenuated oxidative damage by lowering malondialdehyde and nitrite concentrations and restored superoxide dismutase, catalase, and glutathione S-transferase activities. On the other hand, acetylcholinesterase activity was reduced in the groups co-administred with NG (80 or 160 mg/kg) and BPA in comparison with the BPA alone-treated group. The present study highlighted the therapeutic potential of NG against BPA-induced cognitive impairment and oxidative damage.
Keywords: Bisphenol A, naringin, cognitive dysfunction, oxidative stress
     
Type of Study: Original Article | Subject: Neurosciences
Received: 2018/12/11 | Accepted: 2019/10/13
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Mahcavinia M, Ahangharpoor A, Zeidooni L, Samimi A, Dehghani M, Alizadeh S et al . Protective Effect of Naringin on Bisphenol A-Induced Cognitive Dysfunction and Oxidative Damage in Rats. Int J Mol Cell Med. 2019; 8 (2)
URL: http://ijmcmed.org/article-1-988-en.html


Volume 8, Issue 2 (Int J Mol Cell Med [In press] 2019) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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