Volume 7, Issue 2 (Int J Mol Cell Med 2018)                   Int J Mol Cell Med 2018, 7(2): 69-79 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rafaiee R, Ahmadiankia N. Derived Mesenchymal Stem Cells in Addiction Related Hippocampal Damages. Int J Mol Cell Med 2018; 7 (2) :69-79
URL: http://ijmcmed.org/article-1-836-en.html
1- Addiction Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.
2- School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. , Ahmadian@shmu.ac.ir
Abstract:   (7691 Views)
The brain is an important organ that controls all sensory and motor actions, memory, and emotions. Each anatomical and physiological modulation in various brain centers, results in psychological, behavioral, and sensory-motor changes. Alcohol and addictive drugs such as opioids and amphetamines have been shown to exert a great impact on brain, specifically on the hippocampus. Emerging evidence has indicated that altered hippocampal neurogenesis is associated with the pathophysiology of neuropsychological disorders including addiction. The addictive drugs impair neurogenesis and undermine the function of neural stem/progenitor cells in hippocampus. This feature was claimed to be one of the underlying mechanisms of behavioral changes in patients with addiction. As the impairment of stem cells’ function has been proved to be the underlying cause of pathologic neuroadaptations in the brain, the administration of stem cell populations has shown promising results for re-modulating of neuronal status in the brain and especially in the hippocampus. Among different types of stem cells, bone marrow derived mesenchymal stem cells are the most proper candidates for stem cell therapies. In this review article, the recent studies on the effects of addictive drugs on brain neurogenesis, and also the promising potential effects of stem cells in curing addiction related hippocampal damages are discussed.
Full-Text [PDF 226 kb]   (2676 Downloads)    
Type of Study: Review | Subject: Neurosciences
Received: 2018/03/16 | Accepted: 2018/06/13 | Published: 2018/06/20

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 CC BY-NC 4.0 | International Journal of Molecular and Cellular Medicine IJMCM

Designed & Developed by : Yektaweb