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:: Volume 7, Issue 2 (Int J Mol Cell Med [In press] 2018) ::
Int J Mol Cell Med 2018, 7(2): 0-0 Back to browse issues page
The Growth Arrest-Specific Transcript 5 (GAS5) and Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1): Novel Markers Involved in Multiple Sclerosis
Jalal Gharesouran 1, Mohammad Taheri 2, Arezou Sayad 1, Soudeh Ghafouri-Fard 1, Mehrdokht Mazdeh 3, Mir Davood Omrani * 4
1- Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3- Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
4- Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , davood_omrani@yahoo.co.uk
Abstract:   (542 Views)
Recent studies have revealed that long non-coding RNAs (lncRNAs) are connected with pathogenesis of neurodegenerative diseases. Additionally, glucocorticoids have fundamental regulatory roles on the immune system, and act as potent therapeutic compounds for autoimmune and inflammatory diseases. The long noncoding RNA growth arrest-specific 5 (GAS5) which accumulates inside the cells in response to cellular starvation/growth arrest, acts as a potent repressor of the glucocorticoid receptor (GR) through its glucocorticoid response element (GRE). The aim of the present study was to investigate the role of lncRNA GAS5 and its downstream target Nuclear Receptor Subfamily 3 Group C Member 1(NR3C1) in the pathogenesis of multiple sclerosis (MS), and to define the role of GAS5 in the regulation of NR3C1 expression. Quantitative polymerase chain reaction was performed for investigating the expression of GAS5 and NR3C1 in MS patients and healthy subjects. We found that GAS5 levels were up-regulated in blood of MS patients compared with healthy subjects in correlation with NR3C1 expression. Our findings suggest that GAS5 may play important role in the molecular etiology and treatment of MS.
Keywords: Multiple sclerosis, GAS5, NR3C1
     
Type of Study: Original Article | Subject: Genetics & Disease
Received: 2018/02/24 | Accepted: 2018/03/12 | Published: 2018/05/7
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Gharesouran J, Taheri M, Sayad A, Ghafouri-Fard S, Mazdeh M, Omrani M D. The Growth Arrest-Specific Transcript 5 (GAS5) and Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1): Novel Markers Involved in Multiple Sclerosis. Int J Mol Cell Med. 2018; 7 (2)
URL: http://ijmcmed.org/article-1-821-en.html


Volume 7, Issue 2 (Int J Mol Cell Med [In press] 2018) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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