VCAM1 and ICAM1 expression in oral lichen planus

Seyedmajidi, Maryam; Shafaee, Shahryar; Bijani, Ali; Bagheri Moghaddam, Soodabeh

Volume 2, Issue 1 (Int J Mol Cell Med 2013) Int J Mol Cell Med 2013, 2(1): 34-40 | Back to browse issues page

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Seyedmajidi M, Shafaee S, Bijani A, Bagheri Moghaddam S. VCAM1 and ICAM1 expression in oral lichen planus . Int J Mol Cell Med 2013; 2 (1) :34-40
URL: http://ijmcmed.org/article-1-78-en.html

VCAM1 and ICAM1 expression in oral lichen planus

Maryam Seyedmajidi¹

, Shahryar Shafaee²

, Ali Bijani³

, Soodabeh Bagheri Moghaddam⁴

1- Dental Materials Research Center, Dental Faculty, Babol University of Medical Sciences, Babol, Iran. , ms_majidi79@yahoo.com
2- Cellular & Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
3- Non-communicable Pediatrics Diseases Research Center, Babol University of Medical Sciences, Babol, Iran.
4- Students Research Committee, Babol University of Medical Sciences, Babol, Iran.

Abstract: (14227 Views)

Oral lichen planus is a chronic inflammatory immune-mediated disease. ICAM-1 and VCAM-1 are vascular adhesion molecules that their receptors are located on endothelial cells and leukocytes. The aim of this study is the immunohistochemical evaluation of VCAM1 and ICAM1 in oral lichen planus and to compare these two markers with normal mucosa for evaluation of angiogenesis. This descriptive-analytical study was performed on 70 paraffined blocks of oral lichen planus and 30 normal mucosa samples taken from around the lesions. Samples were stained with H & E and then with Immunohistochemistry using monoclonal mouse anti human VCAM1 (CD106), & monoclonal mouse anti human ICAM1(CD54) for confirmation of diagnosis. Slides were evaluated under light microscope and VCAM1 and ICAM1 positive cells (endothelial cells and leukocytes) were counted. Data were analyzed with Mann-Whitney test, Wilcoxon and Chi-Square and p<0.001 was declared significant. VCAM1 and ICAM1 expression significantly increased compared to normal mucosa in oral lichen planus according to the percentage of stained cells (p=0.000& p=0.000, Mann-Whitney test). Thirty cases of oral normal mucosa associated with lichen planus showed that the VCAM1 has increased significantly in comparison to normal mucosa (p<0.001). Also, ICAM1 expression between lichen planus and normal mucosa, showed a significantly difference (p<0.001). A significant difference between VCAM1 and ICAM1 expression and type of lichen planus was not observed (p>0.05). Regarding the results, it seems that high expression of VCAM1 and ICAM1 is related to oral lichen planus.

Keywords: oral lichen planus, angiogenesis, VCAM1, ICAM1

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Type of Study: Original Article | Subject: Histopathology
Received: 2013/03/14 | Accepted: 2013/06/22 | Published: 2013/06/22