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:: Volume 6, Number 3 (Int J Mol Cell Med (In press) 2017) ::
Int J Mol Cell Med 2017, 6(3): 0-0 Back to browse issues page
Association of MiR-146a Expression and Type 2 Diabetes Mellitus: A Meta-Analysis
Behnam Alipoor1, Hamid Ghaedi2, Reza Meshkani3, Shahram Torkamandi2, Sana Saffari4, Mostafa Iranpour2, Mir Davood Omrani *5
1- Department of Laboratory Sciences, Faculty of Paramedicine, Yasuj University of Medical Sciences, Yasuj, Iran., Department of Laboratory Sciences, Faculty of Paramedicine, Yasuj University of Medical Sciences, Yasuj, Iran.
2- Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3- Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
4- Department of Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran., Department of Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran.
5- Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , davood_omrani@yahoo.co.uk
Abstract:   (497 Views)

Although deregulation of miR-146a has been reported in type 2 diabetes repeatedly, the direction of deregulation events (up or down) remained to be inconsistent in literatures.  Therefore, in this study, we performed a meta-analysis on the possible association between miR-146a expression levels and type 2 diabetes. A systematic literature searching of PubMed, ISI Web of Science and Google Scholar was performed up to the end of September 2016. Finally, a total of 12 studies including 344 diabetic patients and 316 controls were selected for meta-analysis. All statistical analysis was performed using the meta for package with R software. Moreover, publication bias was assessed by Egger’s and sensitivity analysis was applied on the meta-analysis. The results are presented as log10 odds ratios (logORs), 95% confidence intervals (CI) with relevant P values. The results revealed that miR-146a was downregulated in type 2 diabetes cases compared with normal subjects (P=0.01, logOR:-4.76, 95% CI:-8.41, -1.11). Furthermore, sub-group analysis showed that the association between miR-146a expression levels and type 2 diabetes in whole blood (P<0.001) and PBMCs (P<0.001) samples were significant. However, this association was not significant in the serum (P=0.67) and plasma (P=0.90) samples. Our finding suggests that miR-146a downregulation could be associated with type 2 diabetes susceptibility. Further investigations with larger sample size are required to evaluate this association in the type 2 diabetes pathogenesis.
 

Keywords: Type 2 diabetes, microRNA-146a, meta-analysis
Full-Text [PDF 381 kb]   (146 Downloads)    
Type of Study: Review | Subject: Genetics & Disease
Received: 2017/05/13 | Accepted: 2017/07/18 | Published: 2017/08/14
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Alipoor B, Ghaedi H, Meshkani R, Torkamandi S, Saffari S, Iranpour M et al . Association of MiR-146a Expression and Type 2 Diabetes Mellitus: A Meta-Analysis. Int J Mol Cell Med. 2017; 6 (3)
URL: http://ijmcmed.org/article-1-683-en.html
Volume 6, Number 3 (Int J Mol Cell Med (In press) 2017) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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