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:: Volume 1, Issue 3 (Int J Mol Cell Med 2012) ::
Int J Mol Cell Med 2012, 1(3): 162-167 Back to browse issues page
Hematologic Features of Alpha Thalassemia Carriers
Haleh Akhavan-Niaki 1, Reza Youssefi Kamangari2, Ali Banihashemi3, Vahid Kholghi Oskooei4, Mandana Azizi2, Ahmad Tamaddoni5, Sadegh Sedaghat6, Mohsen Vakili6, Hassan Mahmoudi Nesheli5, Soraya Shabani2
1- Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran. , halehakhavan@yahoo.com
2- Genetic Laboratory of Amirkola Children Hospital, Babol University of Medical Sciences, Babol, Iran.
3- - Genetic Laboratory of Amirkola Children Hospital, Babol University of Medical Sciences, Babol, Iran.
4- Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
5- Non-Communicable Pediatric Diseases Research Center, Babol University of Medical Sciences, Babol, Iran.
6- Ayatollah Roohani Hospital, Babol University of Medical Sciences, Babol, Iran.
Abstract:   (10040 Views)
Alpha thalassemia (α-thal) is relatively common worldwide. Most carriers are defective in either one or two alpha globin genes out of four functional ones, with deletions being more common than point mutations. The hematologic features are very important for the selection of the appropriate molecular tests while determining the genotype. The aim of this study was to compare hematologic features of patients with various types of α globin mutations. Hematological indices including red blood cells (RBC), hemoglobin concentration (Hb), mean cell volume (MCV), mean cell hemoglobin (MCH), Mean corpuscular hemoglobin concentration (MCHC) and percentage of Hemoglobin (HBA1, HBA2 and HBF) of seven-hundred and twenty two patients presenting ten different α-thal genotypes were considered. All patients showed reduced MCV and/or MCH values. Moreover, MCV and MCH were lower in patients with two functional alpha globin genes in comparison to patients with one mutated alpha globin gene (P value<0.001). In conclusion, MCV and MCH values can be helpful for the selection of the appropriate molecular tests to determine the genotype of alpha thalassemia carriers.
Keywords: Alpha thalassemia, Mean cell volume, Mean cell hemoglobin, Mutation
Full-Text [PDF 84 kb]   (2581 Downloads)    
Type of Study: Original Article | Subject: Genetics & Disease
Received: 2013/01/30 | Accepted: 2013/03/11 | Published: 2013/03/11
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Akhavan-Niaki H, Youssefi Kamangari R, Banihashemi A, Kholghi Oskooei V, Azizi M, Tamaddoni A, et al . Hematologic Features of Alpha Thalassemia Carriers. Int J Mol Cell Med. 2012; 1 (3) :162-167
URL: http://ijmcmed.org/article-1-62-en.html


Volume 1, Issue 3 (Int J Mol Cell Med 2012) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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