Polymorphism of Genes and Implantation Failure

Mojarad, majid; Hassanzadeh-Nazarabad, Mohammad; Tafazoli, Niaiesh

Volume 2, Issue 1 (Int J Mol Cell Med 2013) Int J Mol Cell Med 2013, 2(1): 1-8 | Back to browse issues page

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Mojarad M, Hassanzadeh-Nazarabad M, Tafazoli N. Polymorphism of Genes and Implantation Failure. Int J Mol Cell Med 2013; 2 (1) :1-8
URL: http://ijmcmed.org/article-1-55-en.html

Polymorphism of Genes and Implantation Failure

Majid Mojarad¹

, Mohammad Hassanzadeh-Nazarabad²

, Niaiesh Tafazoli¹

1- Department Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2- Medical Genetics Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. , nazarabadim@mums.ac.ir

Abstract: (12807 Views)

Implantation failure is the most frequent cause of pregnancy loss in couples who try to conceive, either in a natural way or using assisted reproductive techniques (ART). Identify the precise mechanisms of implantation failure can lead to identify couples at risk and also providing appropriate therapeutic options to affected couples. Despite the high prevalence of this disorder, a few causing factors are demonstrated so far. Recent studies indicate that genetic factors play an important role in the occurrence of recurrent implantation failure. Although some of these factors, such as numerical chromosomal aneuploidy are known to be causative factors, there are some other factors that solely increase susceptibility to this event. In the present review we try to list the genetic polymorphisms that are known as susceptibility factors in implantation failure.

Keywords: gene, polymorphism, implantation failure

Full-Text [PDF 70 kb] (3922 Downloads)

Type of Study: Review | Subject: Genetics & Disease
Received: 2013/01/8 | Accepted: 2013/06/22 | Published: 2013/06/22