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Balanced Chromosomal Rearrangement in Recurrent Spontaneous Abortions: A Case Report
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Ahmadreza Zarifian1   , Zeinab Farhoodi1 , Roya Amel1 , Salmahe Mirzaee2 , Mohammad Hassanzadeh-Nazarabad 3 |
1- Student Research Assembly, Mashhad University of Medical Sciences, Iran.
2- Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Iran.
3- Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Iran. , nazarabadim@mums.ac.ir |
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Abstract: (13243 Views) |
| One of the major causes of spontaneous abortion before the fourth month of pregnancy is chromosomal abnormalities. We report an unusual case of a familial balanced chromosomal translocation in a consanguineous couple who experienced 4 spontaneous abortions. Chromosomal studies were performed on the basis of G-banding technique at high resolution and revealed 46, XX, t (16 6) (p12 q26) and 46, XY, t (16 6) (p12 q26) in both partners, which induced such pregnancy complications.
Chromosomal balanced translocation is one of the most common causes of recurrent spontaneous abortions (RSA). In such cases prenatal diagnosis (PND) during the 16th week of gestation is strongly recommended. |
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| Keywords: Chromosomal abnormality, Spontaneous abortion, Chromosomal translocation, Recurrent miscarriage, Case report |
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Full-Text [PDF 315 kb]
(4344 Downloads)
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Type of Study: Case Report |
Subject:
Genetics & Disease
Received: 2013/01/7 | Accepted: 2013/03/17 | Published: 2013/03/17
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