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Relationship of Podoplanin and Glutathione S-transferases T1 Expression with Laryngeal Cancer
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Deniz Kanliada   1, Ender Coskunpinar2 , Kadir Serkan Orhan3 , Yasemin Musteri Oltulu2 , Mehmet Celik3 , Ayse Eren2 , Ilhan Yaylim2 , Kemal Değer3 |
1- Department of ORL and Head&Neck Surgery, Istanbul Faculty of Medicine, Istanbul, Turkey. , ecoskun@istanbul.edu.tr
2- Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
3- Department of ORL and Head&Neck Surgery, Istanbul Faculty of Medicine, Istanbul, Turkey. |
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Abstract: (16328 Views) |
| The aim of this study is to determine whether there is a role of podoplanin and glutathione S-transferases T1 (GST-T1) expression in laryngeal squamous cell carcinoma.
The study was completed with 33 patients and gene expression analysis was performed by qRT–PCR. The podoplanin and GST-T1 expression patterns were analyzed to determine their correlation with clinicopathologic parameters of laryngeal cancer.
Of all patients, 20 had supraglottic, and the remaining 13 had glottic laryngeal cancer. Increased expression of podoplanin was found in 14 tumor tissues, but GST-T1 expression was not detected.
Podoplanin expression did not show any prediction for regional metastasis, thyroid cartilage invasion, lymphatic vessel invasion or tumor differentiation for laryngeal cancer, also there were no significant differences in podoplanin expression between glottic and supraglottic regions, but extracapsullar extension is almost statistically significant (p=0,05). |
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| Keywords: Podoplanin, GST-T1, laryngeal carcinoma, biomarker, squamous cell carcinoma |
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Full-Text [PDF 83 kb]
(3119 Downloads)
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Type of Study: Original Article |
Subject:
Cancer
Received: 2012/12/13 | Accepted: 2013/03/17 | Published: 2013/03/17
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