Volume 5, Issue 3 (Int J Mol Cell Med 2016)                   Int J Mol Cell Med 2016, 5(3): 134-140 | Back to browse issues page

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Torkamandi S, Bastami M, Ghaedi H, Moghadam F, Mirfakhraie R, Omrani M D. MAP3K1 May be a Promising Susceptibility Gene for Type 2 Diabetes Mellitus in an Iranian Population. Int J Mol Cell Med 2016; 5 (3) :134-140
URL: http://ijmcmed.org/article-1-529-en.html
MAP3K1 May be a Promising Susceptibility Gene for Type 2 Diabetes Mellitus in an Iranian Population
Shahram Torkamandi1 , Milad Bastami2 , Hamid Ghaedi1 , Fateme Moghadam3 , Reza Mirfakhraie1 , Mir Davood Omrani4
1- Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
3- Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4- Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , davood_omrani@yahoo.co.uk
Abstract:   (9291 Views)

Considering that MAPK (mitogen- activated protein kinase) signaling pathway has an important role in the progression of inflammatory cytokine secretion in type 2 diabetes mellitus (T2DM), we have recently investigated the reported genetic polymorphism from genome wide association study in MAP3K1 (mitogen-activated protein kinase kinase kinase 1) in diabetes as an important member of MAPK signaling. This study aimed to investigate the possible association of rs10461617 at the upstream of MAP3K1 gene in an Iranian case-control study with the risk of T2DM. The study population was comprised of 342 unrelated Iranian individuals including 177 patients with T2DM and 165 unrelated healthy control subjects. Genotyping was performed using PCR-RFLP and confirmed with sequencing. In a logistic regression analysis, the rs10461617A allele was associated with a significantly higher risk of T2DM assuming the log- additive model (OR: 1.44, 95% CI: 1.01-2.05, P = 0.039). In conclusion, we provided the first evidence for the association of rs10461617 at the upstream of MAP3K1 with the risk of T2DM in an Iranian population.

Keywords: Type 2 diabetes mellitus, genome- wide association study, MAP3K1, cytokines
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Type of Study: Original Article | Subject: Genetics & Disease
Received: 2016/06/1 | Accepted: 2016/07/2 | Published: 2016/08/21
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