The Cross Talk of MicroRNAs and SATB2 Signaling Pathway in Osteogenesis in the Context of Dental Implants

Alsaif, Saad; Alrashidy, Mousa; Al Dossary, Saeed

Volume 0 - Int J Mol Cell Med (Inprees) Int J Mol Cell Med 2025, 0 - Int J Mol Cell Med (Inprees): 0-0 | Back to browse issues page

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Alsaif S, Alrashidy M, Al Dossary S. The Cross Talk of MicroRNAs and SATB2 Signaling Pathway in Osteogenesis in the Context of Dental Implants. Int J Mol Cell Med 2025;
URL: http://ijmcmed.org/article-1-2600-en.html

The Cross Talk of MicroRNAs and SATB2 Signaling Pathway in Osteogenesis in the Context of Dental Implants

Saad Alsaif¹

, Mousa Alrashidy²

, Saeed Al Dossary³

1- Restorative Department Prince Abdulrahman Advanced Dental Institute, Riyadh, Saudi Arabia , saadalsaif48@gmail.com
2- Restorative Department Prince Abdulrahman Advanced Dental Institute, Riyadh, Saudi Arabia
3- 1. Restorative Department, Prince Abdulrahman Advanced Dental Institute, Riyadh, Saudi Arabia.

Abstract: (21 Views)

Dental implant integration is dependent on osteogenesis driven by the transcription factor SATB2, which regulates osteogenic genes. MicroRNAs (miRNAs) modulate SATB2 and influence bone formation. This review evaluates miRNA-SATB2 interactions, non-coding RNAs, and biomaterials in dental implant osseointegration.
A critical review of studies from 2015 to 2025 was conducted to elucidate miRNA-SATB2 interactions and their impact on osteogenesis.
Inhibitory miRNAs (e.g., miR-31, miR-140-5p) suppress SATB2 via the Wnt/β-catenin or SIRT1/Smad3 pathways and reduce osteoblast differentiation. Promoter miRNAs (e.g., miR-17-5p, miR-27a-5p) enhance SATB2 through BMP/Smad signaling. Non-coding RNAs (e.g., lncRNA H19, hsa_circ_0007292) inhibit miRNAs affecting cancellous bone and promote osteogenesis. Biomaterials such as collagen/nanohydroxyapatite (Col/nHA) scaffolds and comorbidities (e.g., osteoporosis) influence outcomes. Inconsistent miRNA roles and limited in vivo data are key gaps.
miRNA- SATB2 interactions are critical for implant success. Patient-specific miRNA profiling and targeted therapies hold promise, pending clinical validation.