International Journal of Molecular and Cellular Medicine (IJMCM)
Babol University of Medical Sciences
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URL: http://ijmcmed.org/article-1-2585-en.html
, Farhad Nikkhahi1 , Fatemeh Zeynali Kelishomi2 , Amir Javadi3 , Sara Sadeghi4 , Behzad Bijani1 , Hamid Sadeghi5 , Hediyeh Saghi Sarabi1 , Seyed Mahmoud Amin Marashi6
2- Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3- Qazvin University of Medical Sciences, Qazvin, Iran
4- Department of Biological Sciences, Idaho State University, Pocatello, Idaho, USA
5- Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran & Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran.
6- Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran ,
Although biofilms on endotracheal tube (ET) surfaces represent a major clinical challenge, studies addressing the effect of lytic bacteriophages on these biofilms are relatively scarce. This study focused on examining the anti-biofilm capability of three specific phage against an XDR isolate of Acinetobacter baumannii in a 48-hour pre-formed biofilm on an ET surface. For this purpose, crystal violet staining, colony counting, and scanning electron microscopy (SEM) were employed. The results demonstrated a significant decrease in biofilm mass and bacterial count after 24 hours of exposure to the phage cocktail. SEM images confirmed a dramatic reduction in the biofilm. Based on these findings, phage therapy has the potential to reduce and disrupt biofilms on ET surfaces.
Received: 2025/04/21 | Accepted: 2025/09/22 | Published: 2025/07/28
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