LINC01366 and LINC01433 in Glioblastoma Multiforme: A Potential Role at the Intersection of Inflammation and Angiogenesis

Jafari, Sorush; Saboori, Masih; Ghasemi, Sorayya

doi:10.22088/IJMCM.BUMS.13.2.160

Volume 13, Issue 2 (Int J Mol Cell Med 2024) Int J Mol Cell Med 2024, 13(2): 160-170 | Back to browse issues page

‎ 10.22088/IJMCM.BUMS.13.2.160

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Jafari S, Saboori M, Ghasemi S. LINC01366 and LINC01433 in Glioblastoma Multiforme: A Potential Role at the Intersection of Inflammation and Angiogenesis. Int J Mol Cell Med 2024; 13 (2) :160-170
URL: http://ijmcmed.org/article-1-2338-en.html

LINC01366 and LINC01433 in Glioblastoma Multiforme: A Potential Role at the Intersection of Inflammation and Angiogenesis

Sorush Jafari¹

, Masih Saboori²

, Sorayya Ghasemi³

1- Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
2- Department of Neurosurgery, School of Medicine Isfahan University of Medical Sciences, Isfahan, Iran.
3- Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran. , Sorayya.ghasemi@gmail.com

Abstract: (695 Views)

Glioblastoma multiforme (GBM) is an aggressive cancer with a poor prognosis. Inflammation and angiogenesis are important processes in GBM that are interrelated. In this study, bioinformatic investigations were performed to detect common and key genes in the inflammatory and angiogenesis pathways of GBM. Additionally, relevant long non-coding RNAs (lncRNAs) were recognized as important gene regulators. Consequently, real-time PCR and correlation analyses were used to investigate changes in gene and lncRNA expression levels and explain their relationship. RELA emerged as a common key gene in these biological processes. LINC01366 and LINC01433 were identified as putative RELA regulators in different metabolic pathways using computational assays. According to our findings, the expression levels of RELA, LINC01366 and LINC01433 were found to be significantly upregulated in GBM samples. Correlational studies revealed a significant positive relationship of gene expressions between LINC01366 and LINC01433, indicating that they may have a coordinated effect on GBM biology. Nevertheless, there was no significant correlation between these lncRNAs and RELA. The current study highlights the high expression of LINC01366 and LINC01433 in GBM and emphasizes the importance of studying lncRNAs as putative regulators in the pathophysiology of GBM. Further research is needed to clarify their specific functions, in particular the associated inflammatory and angiogenesis pathways.

Keywords: LINC01366, LINC01433, RELA, Glioblastoma multiforme, inflammation, angiogenesis

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Type of Study: Original Article | Subject: Genetics & Disease
Received: 2024/05/8 | Accepted: 2024/06/9 | Published: 2024/08/11