Volume 13, Issue 1 (Int J Mol Cell Med 2024)                   Int J Mol Cell Med 2024, 13(1): 19-28 | Back to browse issues page


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Sousa Leite R, Gonçalves da Rocha R, Tamiarana Lima Tabosa A, Batista Gomes E S, Santiago L, Costa Rodrigues D, et al . Cytoprotective Effect of Gallic Acid against Injuries Promoted by Therapeutic Ionizing Radiation in Preosteoblast Cells. Int J Mol Cell Med 2024; 13 (1) :19-28
URL: http://ijmcmed.org/article-1-2298-en.html
1- Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros, Minas Gerais, Brazil.
2- Oncological Radiology Center, Hospital Dilson Godinho, Montes Claros, Minas Gerais, Brazil.
3- Department of Dentistry, Universidade Estadual de Montes Claros, Minas Gerais, Brazil.
4- Institute of Agricultural Sciences, Food Engineering College, Universidade Federal de Minas Gerais, Montes Claros, Minas Gerais, Brazil.
5- Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros, Minas Gerais, Brazil. , lucyana.farias@unimontes.br
Abstract:   (736 Views)
Gallic acid (GA) is a powerful antioxidant extracted from plants of the Brazilian Cerrado. Oxidative stress plays an important role in the occurrence of radiation-induced osteonecrosis in patients treated for head and neck cancer. There is a need to develop research aimed at developing complementary therapies to prevent or reverse bone damage. The aim of the present study was to investigate the effect of GA in preosteoblasts exposed to therapeutic ionizing radiation. MC3T3-E1 preosteoblast cells were treated with 10 µM GA and exposed to 6 Gy ionizing radiation. We performed in vitro assays of cell proliferation, oxidative stress analysis by detection of reactive oxygen species, and alkaline phosphatase assay. GA at lower concentrations was able to significantly increase proliferation and inhibit radiation-induced generation of reactive oxygen species in osteoblast precursor cells, despite ionizing radiation-induced injury. Furthermore, GA significantly increased alkaline phosphatase at a dose of 6 Gy. The findings suggested that GA could attenuate ionizing radiation-induced injuries in osteoblast precursor cells. Moreover, in vivo studies are needed to better investigate the role of GA in osteonecrosis, especially in cancer patients undergoing radiotherapy or taking antiresorptive drugs.
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Type of Study: Original Article | Subject: Other
Received: 2024/02/27 | Accepted: 2024/06/16 | Published: 2024/07/29

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