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:: Volume 4, Issue 1 (Int J Mol Cell Med 2015) ::
Int J Mol Cell Med 2015, 4(1): 46-53 Back to browse issues page
Characterization of Carbapenemases in Extensively Drug Resistance Acinetobacter baumannii in a Burn Care Center in Iran
Leila Azimi1, Malihe Talebi2, Mohammad-Reza Pourshafie3, Parviz Owlia4, Abdolaziz Rastegar Lari 5
1- Antimicrobial Resistance Research Center, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Microbiology, Iran University of Medical Sciences, Tehran, Iran.
3- Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.
4- Molecular Microbiology Research Center, Shahed University, Tehran, Iran.
5- Antimicrobial Resistance Research Center, Iran University of Medical Sciences, Tehran, Iran. , azizlari@gmail.com
Abstract:   (5829 Views)
The emergence of multidrug resistance (MDR) and extensively drug resistance (XDR) in Acinetobacter baumannii has made an important challenge in the treatment of infections caused by this organism. The ability of carbapenemase production is one of the main mechanisms for the emergence of MDR and/or XDR in A. baumannii. The aim of this study was to detect carbapenemase producer A. baumannii. In this study, 65 imipenem resistant A. baumannii were collected from burned patients. Biochemical identification, antibiotic susceptibility test and multiplex polymerase chain reactions for the detection of carbapenemases genes were performed. The results showed that all strains carried blaOXA-51. 83%, 12.5% and 9.23% strains harbored blaOXA-23, blaVIM and blaKPC genes, respectively. None of the isolates carried blaIMP, blaOXA-48, blaNDM-1 and blaSPM-1 genes. The results of this study indicate the emergence of Klebsiella pneumoniae Carbapenemase (KPC) in A. baumannii causing nosocomial infections in burned patients which can be important for hospital infection prevention systems in Iran.
Keywords: Acinetobacter baumannii, carbapenemases, KPC
Full-Text [PDF 96 kb]   (1826 Downloads)    
Type of Study: Original Article | Subject: Medical Pharmacology
Received: 2014/09/10 | Accepted: 2014/11/22 | Published: 2015/01/3
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Azimi L, Talebi M, Pourshafie M, Owlia P, Rastegar Lari A. Characterization of Carbapenemases in Extensively Drug Resistance Acinetobacter baumannii in a Burn Care Center in Iran. Int J Mol Cell Med. 2015; 4 (1) :46-53
URL: http://ijmcmed.org/article-1-226-en.html


Volume 4, Issue 1 (Int J Mol Cell Med 2015) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
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