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Circulating miRNA-106b-5p As a Potential Biomarker for Coronary Artery Disease
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Rosita Azar Bahadori1   , Dina Shabani2 , Elham Arjmandrad3 , Mahsa Kazerani4 , Mina Rohani5 , Zohreh Ramazani Karim6 , Masoud Ali-Kheyl7 , Reza Nosratabadi8 , Hossein Pourghadamyari 9, Mohammad Ali Zaemi10 |
1- Department of Molecular Genetics, Parand Branch, Islamic Azad University, Tehran, Iran.
2- Cellular and Molecular Biology, Department of Biology. Science Faculty, Science and Art University, Yazd, Iran.
3- Department of Molecular and Cellular Sciences, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
4- Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
5- Department of Clinical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
6- Department of Clinical Biochemistry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
7- Department of Clinical Biochemistry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
8- Department of Medical Immunology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
9- Applied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran. , ghadamyarih91@gmail.com
10- Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. |
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Abstract: (173 Views) |
| Coronary artery diseases (CAD) represent a significant global health concern and are recognized as a primary contributor to mortality on a worldwide scale. Early diagnosis of CAD is one of promising goal to manage this disorder. Recent investigations have highlighted the pivotal involvement of microRNAs (miRNAs) in diverse health conditions, notably CAD. The principal objective of this investigation was to identify appropriate miRNAs that could be employed for the early detection of CAD. In the present study, we analyzed dataset of CAD (GSE113079) and 100 differentially expressed mRNAs (DEmRNAs) were detected. The miRNAs that have a significant interaction with DEmRNAs were chosen. By computational prediction method, 5 miRNAs (miR-106b-5p, miR-20a-3p, miR-17-3p, miR-146a-5p, and miR-155-3p) were selected. Finally, we assessed the anticipated expression levels of microRNAs in CAD patients and healthy control groups. Our findings revealed a statistically significant elevation solely in the expression level of miR-106b-5p within the CAD group when compared to the control group (p>0.001). Our study demonstrated an elevation in the expression of miR-106b-5p in individuals diagnosed with CAD. This microRNA may be used as a diagnostic biomarker in patients with CAD. However, further investigations are needed to confirm these results. |
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| Keywords: Circulating miRNA, coronary artery disease, miRNA-mRNA intraction, biomarker |
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Full-Text [PDF 933 kb]
(75 Downloads)
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Type of Study: Original Article |
Subject:
Biomarkers (diagnosis & treatment)
Received: 2023/12/6 | Accepted: 2024/07/7 | Published: 2024/08/28
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Azar Bahadori R, Shabani D, Arjmandrad E, Kazerani M, Rohani M, Ramazani Karim Z, et al . Circulating miRNA-106b-5p As a Potential Biomarker for Coronary Artery Disease. Int J Mol Cell Med 2024; 13 (3) :325-336 URL: http://ijmcmed.org/article-1-2256-en.html
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