[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 3, Issue 4 (Int J Mol Cell Med 2014) ::
Int J Mol Cell Med 2014, 3(4): 263-271 Back to browse issues page
Histopathologic Responses of the Dental Pulp to Calcium-Enriched Mixture (CEM) and Mineral Trioxide Aggregate (MTA) in Diabetic and Non-Diabetic Rats
Zahra Sadat Madani1, Azam Haddadi 2, Abbas Mesgarani3, Maryam Seyedmajidi1, Amrollah Mostafazadeh4, Ali Bijani5, Manouchehr Ashraphpour6
1- Dental Materials Research Center Dental School, Babol University of Medical Sciences, Babol, Iran.
2- Dental School, Mazandaran University of Medical Sciences, Sari, Iran. , ddadi_azam@yahoo.com
3- Dental School, Babol University of Medical Sciences Babol, Iran.
4- Cellular& Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
5- Non–Communicable Pediatric Diseases Research Center Babol University of Medical Sciences, Babol, Iran.
6- Department of pharmacology and Neurosciences, Babol University of Medical Sciences, Babol, Iran.
Abstract:   (5915 Views)
Diabetes mellitus is a chronic disease which affects the healing ability of the pulp and periodontium. The aim of the present study was to assess the histopathologic response of dental pulp to pulp capping using MTA or CEM cement in diabetic rats. Thirty two Wistar male rats aged between 8 and 10 weeks (weight: 200-250g) were divided into two groups of diabetic (n=16) and healthy (n=16) animals and then subdivided into MTA and CEM subgroups. In each group, 10 MTA treated, 10 CEM treated and 12 intact (without any intervention) teeth were analyzed. Intact teeth were considered as a baseline inflammation control. Then, class I cavity was made in the maxillary first molars teeth with pinpoint pulpal exposure. Either MTA or CEM cement was then placed over exposed pulp as pulp capping agent and the cavities were restored using resin- modified glass ionomer cement. Both teeth of rats in subgroups remained intact without any intervention. After four weeks, the rats were sacrificed and the teeth were subjected to histological evaluation in terms of inflammation intensity, dentin bridge formation and dentin bridge continuity. The CEM cement treated diabetic rats exhibited a significant higher inflammatory response when compared to healthy control group (P=0.004) whereas, MTA treated diabetic rats did not exhibit a significant higher inflammatory response in comparison to healthy controls. There was no significant difference between MTA and CEM cement in the induction of dentin bridge formation in diabetic and healthy controls. This preliminary study suggests that MTA is a superior dental material than CEM cement for pulp therapy in subjects with diabetes.
Keywords: Diabetes, direct pulp capping, CEM cement, MTA
Full-Text [PDF 2242 kb]   (1898 Downloads)    
Type of Study: Original Article | Subject: Histopathology
Received: 2014/06/11 | Accepted: 2014/09/15 | Published: 2014/10/1
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Madani Z S, Haddadi A, Mesgarani A, Seyedmajidi M, Mostafazadeh A, Bijani A et al . Histopathologic Responses of the Dental Pulp to Calcium-Enriched Mixture (CEM) and Mineral Trioxide Aggregate (MTA) in Diabetic and Non-Diabetic Rats. Int J Mol Cell Med. 2014; 3 (4) :263-271
URL: http://ijmcmed.org/article-1-175-en.html


Volume 3, Issue 4 (Int J Mol Cell Med 2014) Back to browse issues page
International Journal of Molecular and Cellular Medicine (IJMCM) International Journal of Molecular and Cellular Medicine (IJMCM)
Persian site map - English site map - Created in 0.04 seconds with 30 queries by YEKTAWEB 4219